A5557812
Mecamylamine hydrochloride , 98% , 826-39-1
Synonym(s):
2-(Methylamino)isocamphane hydrochloride;Inversine;N,2,3,3-Tetramethylbicyclo[2.2.1]heptan-2-amine hydrochloride
CAS NO.:826-39-1
Empirical Formula: C11H22ClN
Molecular Weight: 203.75
MDL number: MFCD00151462
EINECS: 212-555-8
Pack Size | Price | Stock | Quantity |
5MG | RMB255.20 | In Stock |
|
25MG | RMB987.20 | In Stock |
|
100MG | RMB3119.20 | In Stock |
|
others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
Melting point: | >240°C (dec.) |
storage temp. | 2-8°C |
solubility | ethanol: 122 mg/mL |
pka | pKa 11.2(H2O,t undefined,I=0.1) (Uncertain) |
form | Solid |
color | White to off-white |
Stability: | Hygroscopic |
CAS DataBase Reference | 826-39-1(CAS DataBase Reference) |
EPA Substance Registry System | Bicyclo[2.2.1]heptan-2-amine, N,2,3,3-tetramethyl-, hydrochloride (1:1) (826-39-1) |
Description and Uses
Mecamylamine hydrochloride is a non-competitive nicotinic acetylcholine receptor antagonist with preferential activity at the α3β4 subtype (IC50 = 90-640 nM) compared to α4β2, α3β2, and α7 subtypes (IC50 range from 1-7 μM), previously used to treat hypertension.Displays antidepressant-like effects in mice.
Mecamylamine HCl is supplied as tablets for oral use, each containing 2.5 mg mecamylamine HCl. Inactive ingredients are calcium phosphate, D&C Yellow 10, FD&C Yellow 6, lactose, magnesium stearate, cornstarch, and talc.
A noncompetitive nicotinic AChR inhibitor.
Safety
Symbol(GHS) | GHS06 |
Signal word | Danger |
Hazard statements | H301 |
Precautionary statements | P301+P330+P331+P310 |
Hazard Codes | Xn |
Risk Statements | 22-36/37/38 |
Safety Statements | 36/37/39 |
RIDADR | UN 2811 6.1/PG 3 |
WGK Germany | 3 |
RTECS | RB6900000 |
HazardClass | 6.1 |
HS Code | 2921300000 |