Maprotiline HCl , ≥99%(HPLC) , 10347-81-6
Synonym(s):
9-(γ-Methylaminopropyl)-9,10-dihydro-9,10-ethanoanthracene hydrochloride;Maprotiline hydrochloride
CAS NO.：10347-81-6
Empirical Formula: C20H24ClN
Molecular Weight: 313.86
MDL number: MFCD00079464
EINECS: 233-758-8
| Pack Size | Price | Stock | Quantity |
| 200MG | RMB28.00 | In Stock |
|
| 1G | RMB130.40 | In Stock |
|
| 5G | RMB553.60 | In Stock |
|
| 25G | RMB1900.00 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 230-232°C |
| Flash point: | 9℃ |
| storage temp. | 2-8°C |
| solubility | H2O: 50 mg/mL |
| form | powder |
| color | white |
| Water Solubility | Soluble to 50mg/ml in water. Soluble in ethanol at 10mM |
| Merck | 14,5748 |
Description and Uses
Maprotiline is a tricyclic antidepressant. It binds to the norepinephrine transporter (NET; Kd = 11 nM) and is selective for NET over the serotonin (5-HT) and dopamine transporters (Kds = 5,800 and 1,000 nM, respectively). Maprotiline also binds to the 5-HT receptor subtype 5-HT2A (KI = 51 nM), as well as histamine H1, muscarinic acetylcholine, α1-adrenergic, and dopamine D2 receptors (Kds = 2, 570, 90, and 350 nM, respectively). In vivo, maprotiline inhibits norepinephrine reuptake in rat brain and peripheral tissues. It reduces isolation-induced aggressive behavior and inhibits electrical foot-shock stimulation-induced belligerence in mice when administered at doses ranging from 3 to 10 mg/kg. Maprotiline (20 μM) prevents acid sphingomyelinase activation and subsequent ceramide release induced by infection with replication-deficient vesicular stomatitis virus pseudoviral particles (pp-VSV) presenting the severe acute respiratory coronavirus 2 (SARS-CoV-2) spike protein in Vero cells, an effect that can be overcome with exogenous application of C16 ceramide . Formulations containing maprotiline have been used in the treatment of depression and anxiety. This product is also available as an analytical reference material (Item Nos. 32702 | 33077).
estrogen, with progesterone as oral contraceptive
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P301+P312+P330 |
| Hazard Codes | Xn,T,F |
| Risk Statements | 22-39/23/24/25-23/24/25-11 |
| Safety Statements | 7-16-36/37-45 |
| RIDADR | 3249 |
| WGK Germany | 3 |
| RTECS | KJ4555000 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| HS Code | 2921490002 |
| Toxicity | LD50 in mice, rats (mg/kg): ~750, ~900 orally (Hess) |
