Milrinone , ≥99% , 78415-72-2

Synonym(s):
1,6-Dihydro-2-methyl-6-oxo-(3,4ʹ-bipyridine)-5-carbonitrile;1,6-Dihydro-2-methyl-6-oxo-(3,4′-bipyridine)-5-carbonitrile;Milrinone - CAS 78415-72-2 - Calbiochem

CAS NO.：78415-72-2

Empirical Formula: C12H9N3O

Molecular Weight: 211.22

MDL number: MFCD00133539

EINECS: 278-903-6

PRODUCT Properties

• Melting point: >3000C
• Boiling point: 350.9°C (rough estimate)
• Density: 1.1922 (rough estimate)
• refractive index: 1.5700 (estimate)
• storage temp.: 2-8°C
• solubility: DMSO: >10 mg/mL
• pka: 7.21±0.10(Predicted)
• form: powder
• color: off-white
• Water Solubility: Soluble in DMSO. Insoluble in water.
• Merck: 14,6197
• Stability: Stable. Incompatible with strong oxidizing agents.
• InChIKey: FYEJSUDMDUIMKJ-UHFFFAOYSA-N

Description and Uses

Milrinone, an inhibitor of phosphodiesterase selective for fraction III PDE, exerts a positive inotropic effect on the heart as well as a peripheral vasodilatory effect. Milrinone given intravenously produces significant improvements on cardiac output, pulmonary capillary wedge pressure and vascular resistance without significant effects on the heart rate.

It is used (particularly intravenously, as the lactate) for the short-term management of severe heart failure. Milrinone inhibits the action of phosphodiesterase-3 preventing degradation of cAMP. The corresponding increase in cAMP levels leads to increased activation of protein kinase A. It is a selective phosphodiesterase inhibitor with vasodilating and positive inotropic activity.

Safety

• Symbol(GHS): GHS06
• Signal word: Danger
• Hazard statements: H301
• Precautionary statements: P301+P330+P331+P310
• Hazard Codes: T,T+
• Risk Statements: 23/24/25-26/27/28
• Safety Statements: 36/37/39-45-22
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• RTECS: DW1762000
• HazardClass: 6.1(b)
• PackingGroup: III
• HS Code: 29337900