5-Methoxytryptamine , 97% , 608-07-1

Synonym(s):
5-Methoxytryptamine;5-Methoxytryptamine hydrochloride;2-(5-Methoxyindol-3-yl)ethylamine;3-(2-Aminoethyl)-5-methoxyindole;5-MOT

CAS NO.：608-07-1

Empirical Formula: C11H14N2O

Molecular Weight: 190.24

MDL number: MFCD00005662

EINECS: 210-153-7

PRODUCT Properties

• Melting point: 121-123 °C (lit.)
• Boiling point: 325.75°C (rough estimate)
• Density: 1.0815 (rough estimate)
• refractive index: 1.5700 (estimate)
• storage temp.: 2-8°C
• solubility: Chloroform (Slightly), Methanol (Slightly)
• pka: 16.91±0.30(Predicted)
• form: crystalline
• color: white
• Merck: 13,6032
• BRN: 145587
• InChI: InChI=1S/C11H14N2O/c1-14-9-2-3-11-10(6-9)8(4-5-12)7-13-11/h2-3,6-7,13H,4-5,12H2,1H3
• InChIKey: JTEJPPKMYBDEMY-UHFFFAOYSA-N
• SMILES: N1C2=C(C=C(OC)C=C2)C(CCN)=C1

Description and Uses

5-Methoxytryptamine (5-MT), also known as mexamine, is a tryptamine derivative closely related to the neurotransmitters serotonin and melatonin. 5-MT has been shown to occur naturally in the body in low levels.It is biosynthesized via the deacetylation of melatonin in the pineal gland.
The protective effect of 5-methoxytryptamine (a metabolite of melatonin) in human keratinocytes against ultraviolet B (UVB) radiation was studied.
Melatonin and its metabolites ameliorate ultraviolet B-induced damage in human epidermal keratinocytes.

5-Methoxytryptamine (Mexamine, Methoxytryptamine) is a tryptamine derivative that is closely related to the neurotransmitter Melatonin (M215000) and Serotonin (S274980). It acts as a full agonist at the 5-HT1, 5-HT2, 5-HT4, 5-HT6, and 5-HT7 receptors but has no affinity for the 5-HT3 receptor.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302
• Precautionary statements: P301+P312+P330
• Hazard Codes: Xn
• Risk Statements: 22-36/37/38-20/21/22
• Safety Statements: 36-26
• WGK Germany: 3
• RTECS: NL4110000
• F: 8
• HS Code: 29339900
• Toxicity: LD50 intraperitoneal in mouse: 176mg/kg