Mebendazole , Analysis standard , 31431-39-7
Synonym(s):
5-Benzoyl-2-benzimidazolecarbamic acid methyl ester;Mebendazol;Methyl N-(5-benzoyl-1H-benzimidazol-2-yl)carbamate
CAS NO.：31431-39-7
Empirical Formula: C16H13N3O3
Molecular Weight: 295.29
MDL number: MFCD00057872
EINECS: 250-635-4
| Pack Size | Price | Stock | Quantity |
| 250MG | RMB39.20 | In Stock |
|
| 5G | RMB135.20 | In Stock |
|
| 25G | RMB413.60 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 288.5°C |
| Boiling point: | 436.98°C (rough estimate) |
| Density | 1.1952 (rough estimate) |
| refractive index | 1.6500 (estimate) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | Practically insoluble in water, in alcohol and in methylene chloride. |
| pka | pKa 3.43/9.93(H2O,t =25,I=0.025) (Uncertain) |
| form | Solid |
| color | White to Pale Beige |
| Water Solubility | 35.4mg/L(25 ºC) |
| Merck | 14,5768 |
| BRN | 759809 |
| BCS Class | 2,4 |
Description and Uses
Mebendazole is a broad-spectrum anthelmintic that is active against both larval and adult stages of nematodes selectively binding the β-subunit of tubulin, thereby inhibiting intestinal microtubule synthesis in the parasite (IC50 = 0.19 μM for Giardia in vitro). As a tubulin-binding agent, mebendazole also possesses antitumor properties, inducing apoptosis of various human carcinomas both in vitro and in vivo, thus preventing their growth and migration. Furthermore, mebendazole has been used to inhibit hedgehog signaling in cancer cells via suppression of the formation of the primary cilium, a microtubule-based organelle that functions as a signaling hub for hedgehog pathway activation. Additionally, mebendazole has been shown to stabilize the transcriptional activator HIF-1α and its downstream targets, abrogating oxidative neuronal death in primary neurons.
For the treatment of Enterobius vermicularis (pinworm), Trichuris trichiura (whipworm), Ascaris lumbricoides (common roundworm), Ancylostoma duodenale (common hookworm), Necator americanus (American hookworm) in single or mixed infections.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P301+P312+P330 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| Safety Statements | 36 |
| RIDADR | UN 2811 |
| WGK Germany | 3 |
| RTECS | EY8600000 |
| HS Code | 29339900 |
| Toxicity | LD50 orally: >80 mg/kg in sheep; >40 mg/kg in mice, rats and chickens (Van Gelder) |
