Methylglyoxal , 40%solution , 78-98-8

Synonym(s):
Acetylformaldehyde;Methylglyoxal solution;Pyruvaldehyde;Pyruvic aldehyde

CAS NO.：78-98-8

Empirical Formula: C3H4O2

Molecular Weight: 72.06

MDL number: MFCD00006960

EINECS: 201-164-8

PRODUCT Properties

• Melting point: 25 °C
• Boiling point: 72 °C
• Density: 1.19 g/mL at 20 °C
• vapor pressure: 25.09hPa at 20℃
• refractive index: n20/D 1.4209
• FEMA: 2969 | PYRUVALDEHYDE
• RTECS: UZ0700000
• storage temp.: 2-8°C
• solubility: DMSO (Slightly), Methanol (Slightly), Water (Soluble)
• form: Solution
• color: Clear yellow to yellow-brown
• Odor: at 1.00 % in propylene glycol. sweet acidic ethereal brown rum
• Odor Type: caramellic
• Water Solubility: >=10 g/100 mL at 17 ºC
• Sensitive: Air Sensitive
• Merck: 14,6081
• JECFA Number: 937
• BRN: 906750
• InChIKey: AIJULSRZWUXGPQ-UHFFFAOYSA-N
• LogP: -1.06 at 25℃
• CAS DataBase Reference: 78-98-8(CAS DataBase Reference)
• IARC: 3 (Vol. 51) 1991
• NIST Chemistry Reference: Propanal, 2-oxo-(78-98-8)
• EPA Substance Registry System: Methylglyoxal (78-98-8)

Description and Uses

Methylglyoxal (MG) is a highly reactive a-dicarbonyl compound that is primarily generated endogenously during glycolytic pathways (glucose and fructose metabolism) in cells and exogenously due to autoxidation of sugar, degradation of lipids, and fermentation during food and drink processing. Methylglyoxal polymerizes readily; it is hygroscopic and incompatible with strong oxidizing agents and bases. Methylglyoxal may be present as a free molecule in the diet or bound to biological materials, such as proteins, and as advanced glycation end products (AGEs), which are poorly absorbed. Methylglyoxal has been indicated in pathological events associated with hyperglycemia in both type 1 and type 2 diabetes and in other diabetic complications as either a direct toxin or as a precursor for AGEs. In animal studies, MG has been shown to induce tumorigenesis, but has also been reported as a tumoristatic agent. Methylglyoxal has been identified as the dominant antibacterial constituent of manuka honey.

Used in organic synthesis, as a flavoring agent, and in tanning leather. Commercial formulation is available as a 30% aqueous solution. No safety concern at current levels of intake when used as a flavoring agent.

Safety

• Symbol(GHS): GHS05,GHS07,GHS08
• Signal word: Danger
• Hazard statements: H290-H317-H318-H341
• Precautionary statements: P202-P234-P280-P302+P352-P305+P351+P338-P308+P313
• Hazard Codes: Xn,Xi,C
• Risk Statements: 22-36-35
• Safety Statements: 26-36-45-36/37/39
• RIDADR: UN 3265 8 / PGIII
• WGK Germany: -
• Hazard Note: Irritant
• TSCA: Yes
• HS Code: 29121900
• Hazardous Substances Data: 78-98-8(Hazardous Substances Data)