A5408312
1-Methylpiperazine , Analysis of standard products, ≥99.5%(GC) , 109-01-3
Synonym(s):
1-Methylpiperazine;N-Methylpiperazine
CAS NO.：109-01-3
Empirical Formula: C5H12N2
Molecular Weight: 100.16
MDL number: MFCD00005966
EINECS: 203-639-5
| Pack Size | Price | Stock | Quantity |
| 5ML | RMB183.20 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | -6 °C |
| Boiling point: | 138 °C(lit.) |
| Density | 0.903 g/mL at 25 °C(lit.) |
| vapor density | 3.5 (vs air) |
| vapor pressure | 12 hPa (20 °C) |
| refractive index | n |
| Flash point: | 108 °F |
| storage temp. | 2-8°C |
| solubility | Chloroform (Soluble), Methanol (Soluble) |
| form | Liquid |
| pka | pK1:4.94(+2);pK2:9.09(+1) (25°C,μ=0.1) |
| Specific Gravity | 0.903 |
| color | Clear |
| PH | 11-12 (50g/l, H2O, 20℃) |
| explosive limit | 1.2-9.9%(V) |
| Water Solubility | soluble |
| Sensitive | Hygroscopic |
| BRN | 102724 |
| InChIKey | PVOAHINGSUIXLS-UHFFFAOYSA-N |
| LogP | -0.57 at 25℃ |
| CAS DataBase Reference | 109-01-3(CAS DataBase Reference) |
| NIST Chemistry Reference | Piperazine, 1-methyl-(109-01-3) |
| EPA Substance Registry System | Piperazine, 1-methyl- (109-01-3) |
Description and Uses
1-Methylpiperazine is used in the preparation of 2-(4-methyl-1-piperazinylmethyl)acrylophenone. It is involved in the preparation of 1-(4-methoxy-phenyl)-4-methyl-piperazine by reacting with 1-chloro-4-methoxy-benzene. It acts as an intermediate in the synthesis of active pharmaceutical ingredients like ofloxacin, rifampicin, clozapine, sildenafil, trifluoperazine and zopiclone. Further, it is used as a mimic template in the preparation of molecularly imprinted microspheres. In addition to this, it is used in the generation of difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative.
Safety
| Symbol(GHS) |    GHS02,GHS05,GHS06 |
| Signal word | Danger |
| Hazard statements | H226-H312-H314-H331 |
| Precautionary statements | P210-P260-P280-P304+P340+P310-P305+P351+P338-P370+P378 |
| Hazard Codes | T,F,C,Xi |
| Risk Statements | 10-21-23-34-36/37/38-20/21 |
| Safety Statements | 16-26-36/37/39-45-36 |
| RIDADR | UN 2734 8/PG 2 |
| WGK Germany | 2 |
| RTECS | TM1225000 |
| Autoignition Temperature | 320 °C |
| Hazard Note | Flammable/Toxic/Corrosive/Store under nitrogen |
| TSCA | Yes |
| HazardClass | 3 |
| PackingGroup | III |
| HS Code | 29335995 |
| Toxicity | LD50 orally in Rabbit: 2547 mg/kg LD50 dermal Rabbit 1341 mg/kg |
