Metformin hydrochloride , 97% , 1115-70-4

Synonym(s):
1,1-Dimethylbiguanide hydrochloride;1,1-Dimethylbiguanide, Hydrochloride, AMPK Signaling Activator VII;Metformin;Metformin - CAS 1115-70-4 - Calbiochem

CAS NO.：1115-70-4

Empirical Formula: C4H12ClN5

Molecular Weight: 165.62

MDL number: MFCD00012582

EINECS: 214-230-6

PRODUCT Properties

• Melting point: 223-226 °C(lit.)
• Density: 1.36[at 20℃]
• vapor pressure: 0.001Pa at 25℃
• Flash point: 9℃
• storage temp.: 2-8°C
• solubility: Freely soluble in water, slightly soluble in alcohol, practically insoluble in acetone and in methylene chloride
• pka: 12.4[at 20 ℃]
• form: Powder
• color: White
• Water Solubility: Soluble in water (50 mg/ml), ethanol, and DMSO (50 mM).
• λmax: 233nm(H2O)(lit.)
• Merck: 14,5938
• BCS Class: 3
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 2 months.
• InChIKey: OETHQSJEHLVLGH-UHFFFAOYSA-N
• LogP: -3.5 at 20℃

Description and Uses

Metformin is a biguanide with diverse biological activities. Metformin (250 mg/kg, i.p.) increases hepatic AMPK activity and reduces blood glucose by more than 50% in a liver kinase B1-dependent manner in mice fed normal and high-fat diets, respectively, and reduces blood glucose by 40% in ob/ob mice. It reduces weight gain, hepatic lipid droplet content, and total cholesterol, LDL cholesterol, and triglyceride levels in the plasma of diet-induced obese mice when administered at doses of 10 or 50 mg/kg per day. It also reverses increased hepatic triglyceride and apolipoprotein A5 levels, as well as hepatic steatosis, in a dose-dependent manner in an ob/ob mouse model of non-alcoholic fatty liver disease (NAFLD). Metformin (250 mg/kg) reduces tumor growth in an HCT116 p53^-\- human colon cancer mouse xenograft model, but has no effect on HCT116 p53^-\- tumors overexpressing recombinant S. cerevisiae Ndi1 NADH dehydrogenase, a single-subunit ortholog of the multi-subunit mammalian mitochondrial complex I. Formulations containing metformin have been used in the treatment of type 2 diabetes.

1,1-Dimethylbiguanide hydrochloride is used as an antidiabetic agent, used in polycystic ovary syndrome, non-alcoholic fatty liver disease and diabetes mellitus type 2. It may also reduce weight gain in people taking atypical antipsychotics, used in a study to investigate its role in enhancing the secretions of plasma active glucagon-like peptide-1 (GLP-1) levels.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302
• Precautionary statements: P301+P312+P330
• Hazard Codes: Xn,T,F
• Risk Statements: 22-36/38-39/23/24/25-23/24/25-11
• Safety Statements: 26-36-45-36/37-16-7
• RIDADR: UN1230 - class 3 - PG 2 - Methanol, solution
• WGK Germany: 3
• RTECS: DU1800000
• HS Code: 29252900
• Toxicity: LD50 in rats (mg/kg): 1000 orally, 300 s.c. (Rx Bulletin)