Methyl gallate , 98% , 99-24-1

Synonym(s):
Methyl gallate

CAS NO.：99-24-1

Empirical Formula: C8H8O5

Molecular Weight: 184.15

MDL number: MFCD00002194

EINECS: 202-741-7

PRODUCT Properties

• Melting point: 201-204 °C
• Boiling point: 278.08°C (rough estimate)
• Density: 1.3840 (rough estimate)
• refractive index: 1.5690 (estimate)
• storage temp.: Inert atmosphere,Room Temperature
• solubility: ethanol: 50 mg/mL, clear
• pka: 8.04±0.23(Predicted)
• form: Crystalline Powder
• color: White to slightly beige
• Water Solubility: SOLUBLE IN HOT WATER
• Merck: 14,4345
• BRN: 2113180
• InChIKey: FBSFWRHWHYMIOG-UHFFFAOYSA-N
• LogP: 0.860
• CAS DataBase Reference: 99-24-1(CAS DataBase Reference)
• EPA Substance Registry System: Benzoic acid, 3,4,5-trihydroxy-, methyl ester (99-24-1)

Description and Uses

Methyl gallate is a phenol that has been found in Meliaceae and has diverse biological activities. It reduces adipogenic hormonal stimulation-induced lipid accumulation in 3T3-L1 cells when used at a concentration of 50 μM. Methyl gallate is active against V. cholerae in vitro (MIC = 32 μg/ml) and reduces V. cholerae-induced intestinal fluid accumulation in suckling mice when administered at doses of 50, 100, and 200 mg/kg. It reduces tumor growth and decreases the number of intratumor CD25⁺Foxp3^high regulatory T cells (Tregs) in an EL-4 model of murine lymphoma. Methyl gallate (0.7, 7, and 70 mg/kg) reduces knee joint edema and leukocyte, neutrophil, and mononuclear cell infiltration in a mouse model of zymosan-induced arthritis.

Methyl gallate exhibits potent antitumor activities by inhibiting tumor infiltration of CD4+CD25+ regulatory T cells.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P301+P312+P330-P302+P352-P305+P351+P338
• Hazard Codes: Xn,Xi
• Risk Statements: 22-36/37/38-43
• Safety Statements: 26-36/37-24/25
• WGK Germany: 3
• RTECS: LW8000000
• TSCA: Yes
• HS Code: 29182900