Methylene blue , Indicator level , 7220-79-3

Synonym(s):
Methylene blue;Methylthioninium chloride;Methylene Blue trihydrate;Methylene Blue hydrate;Methylthionini chloridum

CAS NO.：7220-79-3

Empirical Formula: C16H24ClN3O3S

Molecular Weight: 373.9

MDL number: MFCD00150008

EINECS: 615-731-6

PRODUCT Properties

• Melting point: 190 °C (dec.)(lit.)
• Density: 0.98 g/mL at 25 °C
• Flash point: 14 °C
• storage temp.: no restrictions.
• solubility: Soluble in water, chloroform; sparingly soluble in ethanol
• form: Solid
• pka: 2.6, 11.2(at 25℃)
• Colour Index: 52015
• color: Green
• Water Solubility: 4 g/100 mL
• λmax: 668 nm, 609 nm
• Merck: 13,6085
• Stability: Stable. Incompatible with bases, reducing agents, strong oxidizing agents.
• Biological Applications: Diagnosis of tauopathy,Alzheimer’s disease (AD),Pick’s disease; treating prophylaxis; dental materials
• InChIKey: YAFGUSOAMIMROI-UHFFFAOYSA-M

Description and Uses

Methylene Blue trihydrate finds many uses in biology and chemistry. It acts as a GCS inhibitor, biological stain and redox indicator. It inhibits tau filament formation. Further, it is reported to bind to the M2 subtype of muscarinic receptors in rat cardiac myocytes and thus exhibit antimuscarinic effects on IK, ACh and ICa. It also inhibits endothelium-dependent relaxation of isolated blood vessels.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302
• Precautionary statements: P264-P270-P301+P312-P501
• Hazard Codes: Xn,F
• Risk Statements: 22-36/37/38-11
• Safety Statements: 26-36-24/25-16-7
• RIDADR: UN 1170 3/PG 2
• WGK Germany: 3
• RTECS: SP5740000
• TSCA: Yes
• HS Code: 32129000