Methyl-β-cyclodextrin , averageMn1310 , 128446-36-6

Synonym(s):
Methyl-beta-cyclodextrin;MβCD;MEBCD;Methyl-β-CD;Cavasol W7 M

CAS NO.：128446-36-6

Empirical Formula: C54H94O35

Molecular Weight: 1303.3

MDL number: MFCD00074980

EINECS: 1308068-626-2

PRODUCT Properties

• Melting point: 180-182 °C(lit.)
• alpha: +159°(25℃, c=1, H2O)
• Flash point: 187 °C
• storage temp.: room temp
• solubility: H2O: soluble50mg/mL
• form: powder
• color: White to off-white
• optical activity: [α]25/D +159°, c = 1 in H2O
• Water Solubility: Soluble in water
• InChIKey: YZOUYRAONFXZSI-SBHWVFSVSA-N
• LogP: -2.566 (est)
• EPA Substance Registry System: .beta.-Cyclodextrin, methyl ethers (128446-36-6)

Description and Uses

Methyl-β-cyclodextrin is a randomly methylated form of the cyclic oligosaccharide β-cyclodextrin . Methyl-β-cyclodextrin contains seven D-(+)-glucopyranose units that contain randomized hydrogen or methyl groups. Methyl-β-cyclodextrin has been used to improve the aqueous solubility of various compounds and to extract cholesterol from lipid membranes. Methyl-β-cyclodextrin (5 mM) reduces α-synuclein levels in the membrane and detergent-insoluble fractions from B103 neuroblastoma cells transfected with human α-synuclein. It also reduces α-synuclein levels in mouse brain in a transgenic model of α-synucleinopathy.

Methyl-β-cyclodextrin is a cholesterol-removing agent mainly used for lipid raft disruption. It may also be used for detergent removal from protein-lipid-detergent ternary mixture to produce 2D membrane protein crystals due to its high solubility and affinity for detergents generally used in membrane protein chemistry.

Safety

• Symbol(GHS): GHS08
• Signal word: Warning
• Hazard statements: H317-H361
• Precautionary statements: P201-P202-P261-P272-P280g-P302+P352-P308+P313-P363-P403-P501c
• Safety Statements: 22-24/25
• WGK Germany: 3
• TSCA: Yes
• HS Code: 35051000