Home Categories Biochemical Engineering Methyl-β-cyclodextrin
A5356712

Methyl-β-cyclodextrin , averageMn1310 , 128446-36-6

Synonym(s):
Methyl-beta-cyclodextrin;MβCD;MEBCD;Methyl-β-CD;Cavasol W7 M

CAS NO.:128446-36-6

Empirical Formula: C54H94O35

Molecular Weight: 1303.3

MDL number: MFCD00074980

EINECS: 1308068-626-2

Pack Size Price Stock Quantity
5G RMB95.20 In Stock
25G RMB240.80 In Stock
100G RMB695.20 In Stock
500G RMB2280.00 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 180-182 °C(lit.)
alpha  +159°(25℃, c=1, H2O)
Flash point: 187 °C
storage temp.  room temp
solubility  H2O: soluble50mg/mL
form  powder
color  White to off-white
optical activity [α]25/D +159°, c = 1 in H2O
Water Solubility  Soluble in water
InChIKey YZOUYRAONFXZSI-SBHWVFSVSA-N
LogP -2.566 (est)

Description and Uses

Methyl-β-cyclodextrin is a randomly methylated form of the cyclic oligosaccharide β-cyclodextrin . Methyl-β-cyclodextrin contains seven D-(+)-glucopyranose units that contain randomized hydrogen or methyl groups. Methyl-β-cyclodextrin has been used to improve the aqueous solubility of various compounds and to extract cholesterol from lipid membranes. Methyl-β-cyclodextrin (5 mM) reduces α-synuclein levels in the membrane and detergent-insoluble fractions from B103 neuroblastoma cells transfected with human α-synuclein. It also reduces α-synuclein levels in mouse brain in a transgenic model of α-synucleinopathy.

Methyl-β-cyclodextrin is a cholesterol-removing agent mainly used for lipid raft disruption. It may also be used for detergent removal from protein-lipid-detergent ternary mixture to produce 2D membrane protein crystals due to its high solubility and affinity for detergents generally used in membrane protein chemistry.

Safety

Symbol(GHS) 
GHS08
Signal word  Warning
Hazard statements  H317-H361
Precautionary statements  P201-P202-P261-P272-P280g-P302+P352-P308+P313-P363-P403-P501c
Safety Statements  22-24/25
WGK Germany  3
TSCA  Yes
HS Code  35051000

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