Lamotrigine , ≥98% , 84057-84-1

Synonym(s):
6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine;GI 267119X;Lamotrigine

CAS NO.：84057-84-1

Empirical Formula: C9H7Cl2N5

Molecular Weight: 256.09

MDL number: MFCD00865333

EINECS: 281-901-8

PRODUCT Properties

• Melting point: 177-181°C
• Boiling point: 503.1±60.0 °C(Predicted)
• Density: 1.572±0.06 g/cm3(Predicted)
• Flash point: 9℃
• storage temp.: 2-8°C
• solubility: DMSO: 20 mg/mL at 60 °C, soluble
• form: powder
• pka: 5.7(at 25℃)
• color: white
• Merck: 14,5353
• BCS Class: 2
• InChI: InChI=1S/C9H7Cl2N5/c10-5-3-1-2-4(6(5)11)7-8(12)14-9(13)16-15-7/h1-3H,(H4,12,13,14,16)
• InChIKey: PYZRQGJRPPTADH-UHFFFAOYSA-N
• SMILES: N1C(C2=CC=CC(Cl)=C2Cl)=C(N)N=C(N)N=1
• CAS DataBase Reference: 84057-84-1(CAS DataBase Reference)

Description and Uses

Lamotrigine, also known by the brand name Lamictal®, is a second-generation antiepileptic drug (AED) manufactured by GlaxoSmithKline in the UK and USA. Lamotrigine is a new mazine, glutamate inhibitor anticonvulsant that significantly reduces the incidence of refractory partial seizures. The drug is reported to produce fewer CNS side effects than diazepam or sodium phenytoin. It is also indicated as add-on therapy for the treatment of generalized seizures not satisfactorily controlled by other anti-epileptics.

Lamotrigine is an anticonvulsant that works by Inhibits glutamate release, possibly through inhibition of Sodium, Potassium, and Calcium currents. Used in the treatment of bipolar depression, partial seizures in epilepsy, and generalized seizures of Lennox-Gastaut syndrome. Additionally, it is used for the maintenance treatment of bipolar I disorder and depression.

Safety

• Symbol(GHS): GHS06
• Signal word: Danger
• Hazard statements: H301
• Precautionary statements: P264-P270-P301+P310-P405-P501
• Hazard Codes: T,Xi,F
• Risk Statements: 25-36/37/38-39/23/24/25-23/24/25-11
• Safety Statements: 45-36-26-36/37-16
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• RTECS: XY5850700
• HazardClass: 6.1(b)
• PackingGroup: III
• HS Code: 29336990
• Hazardous Substances Data: 84057-84-1(Hazardous Substances Data)
• Toxicity: LD50 in mice, rats (mg/kg): 250, >640 orally (Sawyer)