Lacidipine , ≥98% , 103890-78-4

Synonym(s):
3,5-Diethyl 4-{2-[(1E)-3-(tert-butoxy)-3-oxoprop-1-en-1-yl]phenyl}-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate;4-[2-[(1E)-3-(1,1-Dimethylethoxy)-3-oxo-1-propen-1-yl]phenyl]-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid 3,5-diethyl ester;CID 5311217;GR-43659X;GX-1048

CAS NO.：103890-78-4

Empirical Formula: C26H33NO6

Molecular Weight: 455.54

MDL number: MFCD00865936

EINECS: 638-759-0

PRODUCT Properties

• Melting point: 174-175°C
• Boiling point: 558.4±50.0 °C(Predicted)
• Density: 1.127±0.06 g/cm3(Predicted)
• storage temp.: 2-8°C
• solubility: DMSO: soluble20mg/mL, clear
• pka: 3.00±0.70(Predicted)
• form: powder
• color: white to beige
• Merck: 14,5331
• InChIKey: GKQPCPXONLDCMU-CCEZHUSRSA-N
• CAS DataBase Reference: 103890-78-4(CAS DataBase Reference)

Description and Uses

Lacidipine is a new second-generation dihydropyridine calcium antagonist introduced as a once a day treatment for mild to moderate hypertension. It is reported to have high selectivity for vascular smooth muscle and also a long duration of action. The use of lacidipine as an antiatherosclerotic agent is currently under investigation.

A dihydropyridine calcium channel blocker. Antihypertensive.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302
• Precautionary statements: P264-P270-P301+P312+P330-P501
• Hazard Codes: Xn
• Risk Statements: 22
• WGK Germany: 3
• RTECS: US7970200
• Toxicity: mouse,LD50,intraperitoneal,80200ug/kg (80.2mg/kg),SKIN AND APPENDAGES (SKIN): HAIR: OTHERSENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYEBEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY),Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 22, Pg. 335, 1994.