Lomefloxacin hydrochloride , 98% , 98079-52-8

Synonym(s):
1-Ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid

CAS NO.：98079-52-8

Empirical Formula: C17H20ClF2N3O3

Molecular Weight: 387.81

MDL number: MFCD00214312

EINECS: 627-337-1

PRODUCT Properties

• Melting point: 290-3000C
• storage temp.: Sealed in dry,Store in freezer, under -20°C
• solubility: 1 M NaOH: soluble50mg/mL
• form: powder to crystal
• color: white to off-white
• biological source: synthetic
• Merck: 14,5562
• CAS DataBase Reference: 98079-52-8(CAS DataBase Reference)

Description and Uses

Lomefloxacin is an orally bioavailable, broad-spectrum fluoroquinolone antibiotic. In vitro, it inhibits growth of N. gonorrhoeae, E. coli, K. pneumoniae, P. vulgaris, S. epidermidis, and M. morganii (MIC₉₀s = 0.1, 0.39, 0.39, 0.39, 0.39, and 0.78 μg/ml, respectively). It also inhibits growth of S. aureus and methicillin-resistant S. aureus (MRSA; MIC₉₀ = 3.13 μg/ml for both) and of H. influenzae and ampicillin-resistant H. influenzae (MIC₉₀ = 0.1 μg/ml for both). In vivo, lomefloxacin inhibits the growth of P. mirabilis, E. coli, K. pneumoniae, and S. aureus (ED₅₀s = 1.39, 1.45, 1.78, and 6.66 mg/kg, respectively) in mouse models of systemic infection. It inhibits bacterial DNA gyrase, thereby inhibiting DNA synthesis and bacterial growth. Formulations containing lomefloxacin have been used in the treatment of bronchitis and urinary tract bacterial infections.

Fluorinated quinolone antibacterial. DNA gyrase antagonist

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H317
• Precautionary statements: P261-P264-P270-P272-P280-P301+P312+P330-P302+P352+P333+P313+P363-P501
• Hazard Codes: Xn
• Risk Statements: 22
• WGK Germany: 3
• RTECS: VB1997500
• HS Code: 29339900