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A5240812

Ketoconazole , ≥98% , 65277-42-1

Synonym(s):
(±)-cis-1-Acetyl-4-(4-[(2-[2,4-dichlorophenyl]-2-[1H-imidazol-1-ylmethyl]-1,3-dioxolan-4-yl)-methoxy]phenyl)piperazine;cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine, R-41400, CYP17A1 Inhibitor I;Ketoconazole;Ketoconazole - CAS 65277-42-1 - Calbiochem

CAS NO.:65277-42-1

Empirical Formula: C26H28Cl2N4O4

Molecular Weight: 531.43

MDL number: MFCD00058579

EINECS: 265-667-4

Pack Size Price Stock Quantity
1G RMB24.00 In Stock
5G RMB37.60 In Stock
25G RMB149.60 In Stock
100G RMB499.20 In Stock
500g RMB2044.00 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 148-152 °C
Boiling point: 753.4±60.0 °C(Predicted)
Density  1.4046 (rough estimate)
refractive index  -10.5 ° (C=0.4, CHCl3)
Flash point: 9℃
storage temp.  2-8°C
solubility  methanol: soluble50mg/mL
pka pKa 3.25/6.22(H2O,t =25,I=0.025) (Uncertain)
form  Off-white solid
color  white to light yellow
optical activity [α]20/D -1 to 1°, c = 4 in methanol
Water Solubility  Soluble in DMSO, ethanol, chloroform, water, and methanol.
Merck  14,5302
BCS Class 2
Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChIKey XMAYWYJOQHXEEK-OZXSUGGESA-N
LogP 4.350
CAS DataBase Reference 65277-42-1(CAS DataBase Reference)

Description and Uses

Ketoconazole (Nizoral), an orally effective broadspectrum antifungal agent, blocks hydroxylating enzyme systems by interacting with cytochrome P450 at the heme iron site to inhibit steroid and/or androgen synthesis in adrenals, gonads, liver, and kidney. The most sensitive site of action appears to be the C17-20 lyase reaction involved in the formation of sex steroids. This explains the greater suppressibility of testosterone production than with cortisol. Cholesterol side-chain cleavage and 11β/18-hydroxylase are secondary sites of inhibition.

An inhibitor of CYP proteins, thromboxane synthetase, and 5-LO

Safety

Symbol(GHS) 
GHS06,GHS08,GHS09
Signal word  Danger
Hazard statements  H301-H360F-H373-H410
Precautionary statements  P201-P202-P260-P264-P273-P301+P310
Hazard Codes  T,N,F
Risk Statements  25-36/37/38-23/24/25-50/53-48/22-60-39/23/24/25-11
Safety Statements  36-45-36/37/39-26-61-60-53-36/37-16-7
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  TK7912300
HazardClass  6.1(b)
PackingGroup  III
HS Code  29349990
Hazardous Substances Data 65277-42-1(Hazardous Substances Data)
Toxicity LD50 in mice, rats, guinea pigs, dogs (mg/kg): 44, 86, 28, 49 i.v.; 702, 227, 202, 780 orally (Heel)

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