Ketoprofen , ≥98%(HPLC) , 22071-15-4

Synonym(s):
2-(3-Benzoylphenyl)propionic acid;Ketoprofen;KP

CAS NO.：22071-15-4

Empirical Formula: C16H14O3

Molecular Weight: 254.29

MDL number: MFCD00055790

EINECS: 244-759-8

PRODUCT Properties

• Melting point: 93-96°C
• Boiling point: 357.5°C (rough estimate)
• Density: 1.1565 (rough estimate)
• refractive index: 1.5600 (estimate)
• storage temp.: 2-8°C
• solubility: Slightly soluble in chloroform and methanol.
• pka: pKa 5.94(MeOH/H2O) (Uncertain)
• form: solid
• color: White to Off-White
• Water Solubility: 209mg/L(room temperature)
• Merck: 14,5305
• InChIKey: DKYWVDODHFEZIM-UHFFFAOYSA-N

Description and Uses

Ketoprofen is a chemical that comes in the form of a white crystalline powder; odorless or nearly odorless. It is very soluble in methanol, soluble in ethanol, acetone or ether, and almost insoluble in water. The melting point is about 93-96 °C. For the arylalkanoic acid compounds. Has analgesic, anti-inflammatory and antipyretic effects. The anti-inflammatory effect is stronger than that of ibuprofen, with less side effects and low toxicity. Oral and easily absorbed from the gastrointestinal tract. After 1 administration, the peak plasma concentration can be reached in about 0.5 to 2 hours. t 1/2 is 1.6 to 1.9 hours. In the blood and plasma protein binding force is extremely strong. The excretion rate from urine is 30% to 90% within 24 hours. Mainly excreted in the form of glucuronic acid conjugates. For rheumatoid arthritis, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis and gout, etc.

Natural Vitamin B12. analog

Safety

• Symbol(GHS): GHS06
• Signal word: Danger
• Hazard statements: H301
• Precautionary statements: P264-P270-P301+P310-P405-P501
• Hazard Codes: T
• Risk Statements: 25-36/37/38-23/24/25
• Safety Statements: 26-45-36/37/39
• RIDADR: 2811
• WGK Germany: 3
• RTECS: UE7570000
• TSCA: Yes
• HazardClass: 6.1(b)
• PackingGroup: III
• HS Code: 29183000
• Toxicity: LD50 orally in rats: 101 mg/kg (Ueno)