Kasugamycin hydrochloride , Analysis of standard products, ≥90%(HPLC) , 19408-46-9

Synonym(s):
3-O-[2-Amino-4-[(carboxyiminomethyl)amino]-2,3,4,6-tetradeoxy-D-arabino-hexopyranosyl]-D-chiro-inositol hydrochloride;3-O-[2-Amino-4-[(carboxyiminomethyl)amino]-2,3,4,6-tetradeoxy-D-arabino-hexopyranosyl]-D-chiro-inositol

CAS NO.：19408-46-9

Empirical Formula: C14H25N3O9.ClH

Molecular Weight: 415.82

MDL number: MFCD00058459

EINECS: 637-144-4

PRODUCT Properties

• Melting point: 202-204 °C (decomp)
• vapor pressure: <1.3x l0^-8 Pa (25 °C)
• storage temp.: Sealed in dry,2-8°C
• solubility: H₂O: soluble
• pka: 3.23 (carboxyl), 7.73 and 11.0 (bases)
• Water Solubility: 125 g l^-1 (25 °C)
• form: Solid
• color: white to off-white
• Stability: Hygroscopic
• CAS DataBase Reference: 19408-46-9(CAS DataBase Reference)
• EPA Substance Registry System: Kasugamycin monohydrochloride (19408-46-9)

Description and Uses

Kasugamycin is an aminoglycosidic antibiotic isolated from S. kasugaensis. It blocks the initiation of translation, preventing initiation complex formation on 30S ribosomes in bacteria.

kasugamycin, derived from Streptomyces kasuguensis, is also used to control rice blast.It acts by inhibiting protein synthesis by interfering with the binding of aminoacyl-tRNA to the mRNA-30s ribosomal subunit complex (Yamaguchi, 1998).

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H320-H335
• Precautionary statements: P261-P280-P301+P312-P302+P352-P305+P351+P338
• Safety Statements: 22-24/25-26
• WGK Germany: 2
• RTECS: NM7521800