Home Categories Ketanserin Tartrate
A5234112

Ketanserin Tartrate , 98% , 83846-83-7

Synonym(s):
3-(2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl)-2,4(1H,3H)-quinazolinedione (+)-tartrate salt;5-HT 2A Serotonin Receptor Antagonist, Ketanserin, R 41 468;Ketanserin Tartrate - CAS 83846-83-7 - Calbiochem;R 41468 (+)-tartrate salt

CAS NO.:83846-83-7

Empirical Formula: C26H28FN3O9

Molecular Weight: 545.52

MDL number: MFCD00084651

EINECS: 281-062-8

Pack Size Price Stock Quantity
10MG RMB143.20 In Stock
50MG RMB359.20 In Stock
250MG RMB599.20 In Stock
1g RMB1599.20 In Stock
5g RMB3679.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 183~186℃
storage temp.  2-8°C
solubility  ethanol: 3.3mg/mL
form  solid
color  white
Water Solubility  Soluble to 10 mM in water
CAS DataBase Reference 83846-83-7(CAS DataBase Reference)

Description and Uses

Ketanserin is a potent antagonist of the serotonin (5-HT) receptor that is selective for 5-HT2 (IC50 = 6.3 nM; Ki = 2.1 nM). It has no activity at 5-HT1 receptors but does have activity at histamine type 1, α1-adrenergic, and dopamine receptors with Ki values of 10, 10, and 220 nM, respectively. Ketanserin induces dose-dependent inhibition of contractile responses to 5-HT in isolated rat caudal artery, canine basilar, carotid, coronary and gastrosplenic arteries, and canine gastrosplenic and saphenous veins. Ketanserin (10 mg/kg/day) significantly decreases blood pressure (BP), blood pressure variability (BPV), and hypertensive organ damage in spontaneously hypertensive rats. Formulations containing ketanserin have been used to treat hypertension in early-onset preeclampsia.

Selective 5-HT2A serotonin receptor antagonist

Safety

Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H301
Precautionary statements  P301+P310
Hazard Codes  T
Risk Statements  25
Safety Statements  22-36/37/39-45
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  VA1411195
HazardClass  6.1
HS Code  29335990
Toxicity LD50 oral in rat: 129mg/kg

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