Ketanserin Tartrate , 98% , 83846-83-7

Synonym(s):
3-(2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl)-2,4(1H,3H)-quinazolinedione (+)-tartrate salt;5-HT _2A Serotonin Receptor Antagonist, Ketanserin, R 41 468;Ketanserin Tartrate - CAS 83846-83-7 - Calbiochem;R 41468 (+)-tartrate salt

CAS NO.：83846-83-7

Empirical Formula: C26H28FN3O9

Molecular Weight: 545.52

MDL number: MFCD00084651

EINECS: 281-062-8

PRODUCT Properties

• Melting point: 183～186℃
• storage temp.: 2-8°C
• solubility: ethanol: 3.3mg/mL
• form: solid
• color: white
• Water Solubility: Soluble to 10 mM in water

Description and Uses

Ketanserin is a potent antagonist of the serotonin (5-HT) receptor that is selective for 5-HT₂ (IC₅₀ = 6.3 nM; K_i = 2.1 nM). It has no activity at 5-HT₁ receptors but does have activity at histamine type 1, α₁-adrenergic, and dopamine receptors with K_i values of 10, 10, and 220 nM, respectively. Ketanserin induces dose-dependent inhibition of contractile responses to 5-HT in isolated rat caudal artery, canine basilar, carotid, coronary and gastrosplenic arteries, and canine gastrosplenic and saphenous veins. Ketanserin (10 mg/kg/day) significantly decreases blood pressure (BP), blood pressure variability (BPV), and hypertensive organ damage in spontaneously hypertensive rats. Formulations containing ketanserin have been used to treat hypertension in early-onset preeclampsia.

Selective 5-HT2A serotonin receptor antagonist

Safety

• Symbol(GHS): GHS06
• Signal word: Danger
• Hazard statements: H301
• Precautionary statements: P301+P310
• Hazard Codes: T
• Risk Statements: 25
• Safety Statements: 22-36/37/39-45
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• RTECS: VA1411195
• HazardClass: 6.1
• HS Code: 29335990
• Toxicity: LD50 oral in rat: 129mg/kg