N,2,3-Trimethyl-2-isopropylbutamide , >98.0%(GC) , 51115-67-4

CAS NO.：51115-67-4

Empirical Formula: C10H21NO

Molecular Weight: 171.28

MDL number: MFCD00130070

EINECS: 256-974-4

PRODUCT Properties

• Melting point: 58-61 °C
• Boiling point: bp0.35mm 83-85°
• Density: 0.9419 (rough estimate)
• vapor pressure: 0.3-0.32Pa at 25℃
• refractive index: 1.4621 (estimate)
• FEMA: 3804 | 2-ISOPROPYL-N,2,3-TRIMETHYLBUTYRAMIDE
• storage temp.: Sealed in dry,Room Temperature
• pka: 16.46±0.46(Predicted)
• form: Solid
• color: White to Almost white
• Odor: at 25.00 % in dipropylene glycol. mild cooling mentholic minty
• Odor Type: minty
• JECFA Number: 1595
• Merck: 14,9716
• LogP: 2.5 at 25℃ and pH7
• CAS DataBase Reference: 51115-67-4(CAS DataBase Reference)
• EPA Substance Registry System: Butanamide, N,2,3-trimethyl-2-(1-methylethyl)- (51115-67-4)

Description and Uses

2-isopropyl-N,2,3-trimethylbutyramide is one nearly odorless white crystalline powder widely used as a coolant in medicinal preparations, oral care products, foodstuffs, cosmetics, and confection-eye products. It is an artificial synthesis cooling agent and could be synthesized by the Ritter reaction of 2,2-diisopropylpropionitrile (DIPPN) with methanol in the presence of acid. Compared with menthol, WS-23 is characterized by a continuous and long-lasting cooling and refreshing effect with no side effects of burning or stinging sensations. As an important additive in menthol cigarettes, WS-23 can cover up the bitter and astringent taste of cigarettes, make the cigarette feel fresh, improve the coordination and softness of cigarette smoke, and reduce the thorn in the mouth and throat. WS-23 is also compatible with other flavors and cooling agents[1].

Physiological coolant in foods, beverages, tobacco products, toiletries, cosmetics and pharmaceuticals.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H319-H302
• Precautionary statements: P264-P280-P305+P351+P338-P337+P313P-P264-P270-P301+P312-P330-P501
• Hazard Codes: Xi
• Risk Statements: 36/37/38-52/53
• Safety Statements: 37/39-26
• HS Code: 29242990