A4982612
Isatin , AR , 91-56-5
Synonym(s):
Isatin;2,3-Indolinedione;Isatine;Isatinic acid anhydride;Isatic acid lactam
CAS NO.：91-56-5
Empirical Formula: C8H5NO2
Molecular Weight: 147.13
MDL number: MFCD00005718
EINECS: 202-077-8
| Pack Size | Price | Stock | Quantity |
| 25G | RMB50.40 | In Stock |
|
| 100g | RMB120.80 | In Stock |
|
| 500g | RMB380.00 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 193-195 °C (dec.) (lit.) |
| Boiling point: | 267.22°C (rough estimate) |
| Density | 1.3067 (rough estimate) |
| vapor pressure | 0Pa at 25℃ |
| refractive index | 1.4700 (estimate) |
| Flash point: | 220 °C |
| storage temp. | Store below +30°C. |
| solubility | soluble |
| pka | 10.34±0.20(Predicted) |
| form | Powder |
| color | Orange |
| PH | 7 (1.9g/l, H2O, 20℃) |
| Water Solubility | Soluble in water (1.9 g/L at 20°C). |
| Decomposition | 194 ºC |
| Merck | 14,5104 |
| BRN | 383659 |
| Stability: | Stable. Incompatible with strong acids. |
| InChIKey | JXDYKVIHCLTXOP-UHFFFAOYSA-N |
| LogP | 0.45 |
| CAS DataBase Reference | 91-56-5(CAS DataBase Reference) |
| NIST Chemistry Reference | Isatin(91-56-5) |
| EPA Substance Registry System | 1H-Indole-2,3-dione (91-56-5) |
Description and Uses
Isatin can be used as a reactant to prepare:
- Phthalazinone derivatives.
- Spirooxindole derivatives.
- Agents against multidrug-resistant cells expressing P-glycoprotein.
- Thiazolidinones spiro-fused to indolin-2-ones as potent and selective inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase B.
- Triazole-isatine compounds as potential antibacterial and antifungal agents.
- Biologically relevant scaffolds such as spiro[indole-thiazolidinones].
It can be a reactant for:
- Cascade reactions with heterocyclic ketene aminals.
- Knoevenagel condensation reactions.
Isatin can also be used as a chromatographic spray reagent for amino acids, and also as a reference material in the preparation of indigo and Maya Blue. It is responsible for the yellow color exhibited by the "Maya Yellow" pigment.
Safety
| Symbol(GHS) |  GHS02 |
| Signal word | Warning |
| Hazard statements | H226 |
| Precautionary statements | P501-P240-P210-P233-P243-P241-P242-P280-P370+P378-P303+P361+P353-P403+P235 |
| Hazard Codes | Xi,Xn |
| Risk Statements | 36/37/38-20/21/22 |
| Safety Statements | 26-36-24/25 |
| RIDADR | 2811 |
| WGK Germany | 1 |
| RTECS | NL7873000 |
| Autoignition Temperature | 220 °C |
| TSCA | Yes |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| HS Code | 29337900 |
