Home Categories 3-Indolepropionic acid
A4980512

3-Indolepropionic acid , 98% , 830-96-6

Synonym(s):
3-(3-Indolyl)propanoic acid;3-(3-Indolyl)propionic acid;Indole-3-propionic acid;IPA

CAS NO.:830-96-6

Empirical Formula: C11H11NO2

Molecular Weight: 189.21

MDL number: MFCD00005660

EINECS: 212-600-1

Pack Size Price Stock Quantity
1G RMB23.20 In Stock
5G RMB24.80 In Stock
25G RMB79.20 In Stock
100G RMB186.40 In Stock
500g RMB798.40 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: ~133 °C
Boiling point: 82 °C(lit.)
Density  0.960 g/mL at 20 °C
vapor density  2.1 (vs air)
vapor pressure  33 mm Hg ( 20 °C)
refractive index  n20/D 1.377(lit.)
Flash point: 53 °F
storage temp.  Sealed in dry,Room Temperature
solubility  ethanol: soluble50mg/mL, clear, yellow to orange
pka 4.77±0.10(Predicted)
form  crystalline
color  light yellow
Water Solubility  slightly soluble
BRN  147733

Description and Uses

Indole-3-propionic acid is a bacterial metabolite that has antioxidant and neuroprotective activities. It scavenges ABTS radicals in a cell-free assay when used at concentrations ranging from 50 to 150 μM and decreases hydrogen peroxide-induced malondialdehyde (MDA) levels in rat striatal membranes (IC50 = 180 μM). Indole-3-propionic acid also decreases increases in MDA levels induced by amyloid β (1-42) in PC12 cells. It decreases ischemia-induced increases in cell death of pyramidal neurons and levels of 4-hydroxy nonenal (HNE; ) and glial fibrillary acidic protein (GFAP) in the hippocampal CA1 region in gerbils when administered at a dose of 10 mg/kg per day.

Reactant for preparation of:

  • Fluorescent analogues of strigolactones
  • Anti-tumor agents
  • Melanocortin receptors ligands
  • Immunosuppressive agents
  • Iinhibitors of hepatitis C virus
  • Histamine H4 receptor agonists
  • NR2B/NMDA receptor antagonists
  • CB1 antagonist for the treatment of obesity
  • Antibacterial agents
  • Inhibitor of TGF-β receptor binding
Indole-3-propionic acid may be used in the synthesis of oxindole-3-propionic acid via reaction with N-bromosuccinimide in acetic acid followed by treatment with H2/Pd catalyst.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Hazard Codes  Xi
Risk Statements  22-36/37/38
Safety Statements  26-37/39
WGK Germany  3
RTECS  NM1329000
8-10-23
TSCA  Yes
HS Code  29339990
Toxicity LDLo intraperitoneal in mouse: 100mg/kg

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