1H-pyrrolo[2,3-b]pyridine-6-carbonitrile , 97% , 189882-33-5

CAS NO.：189882-33-5

Empirical Formula: C8H5N3

Molecular Weight: 143.15

MDL number: MFCD06659673

EINECS: 251-156-6

PRODUCT Properties

• Melting point: 187.4 °C
• Boiling point: 463.9±28.0 °C(Predicted)
• Density: 1.29±0.1 g/cm3(Predicted)
• storage temp.: 2-8°C
• pka: 6.56±0.40(Predicted)

Description and Uses

7-Azaindole, as a bioisostere of indole or purine, is widely used in drug development. Among them, 1H-pyrrolo[2,3-b]pyridine-6-carbonitrile is a key intermediate for the synthesis of a class of selective cyclin-dependent kinase (CDK) 7 inhibitors. Among mammalian CDKs, CDK7 has a unique integrated kinase activity that helps regulate the cell cycle and gene transcription. 1H-pyrrolo[2,3-b]pyridine-6-carbonitrile can be prepared using 7-azaindole-7-oxide as a raw material.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P305+P351+P338
• HS Code: 2933998090