Hexamethonium bromide , 55-97-0
Synonym(s):
Hexamethonium Bromide - CAS 55-97-0 - Calbiochem;Hexane-1,6-bis(trimethylammonium bromide);Hexane-1,6-bis(trimethylammonium bromide), Nicotinic Acetylcholine Receptors (nAChRs) Antagonist, Hexamethonium Bromide;N,N,N,N′,N′,N′-Hexamethylhexamethylenediammonium dibromide
CAS NO.：55-97-0
Empirical Formula: C12H30Br2N2
Molecular Weight: 362.19
MDL number: MFCD00011787
EINECS: 200-249-7
| Pack Size | Price | Stock | Quantity |
| 5G | RMB52.80 | In Stock |
|
| 25G | RMB153.60 | In Stock |
|
| 100G | RMB417.60 | In Stock |
|
| 500G | RMB1670.40 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | ~285 °C (dec.) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Water (Slightly) |
| form | Crystalline Powder and Agglomerates |
| color | White |
| PH | pH (20g/l, 25℃) : 4.5～6.5 |
| Merck | 14,4688 |
| BRN | 3715749 |
| InChIKey | FAPSXSAPXXJTOU-UHFFFAOYSA-L |
| CAS DataBase Reference | 55-97-0(CAS DataBase Reference) |
| EPA Substance Registry System | 1,6-Hexanediaminium, N1,N1,N1,N6,N6,N6-hexamethyl-, bromide (1:2) (55-97-0) |
Description and Uses
Hexamethonium is a peripherally-acting nondepolarizing neuromuscular blocking agent that acts as an antagonist of nicotinic acetylcholine receptors (nAChRs). It decreases acetylcholine release induced by carbamoylcholine in isolated cat superior cervical ganglion when used at concentrations of 27.4 and 54.8 μg/ml. It also decreases mean arterial pressure in unanesthetized rats when administered at a dose of 40 mg/kg. Intraventricular administration of hexamethonium (18 ng, i.c.v.) induces signs of nicotine abstinence, including shaking, writhing, and chewing in nicotine-dependent rats. Formulations containing hexamethonium were previously used in the treatment of hypertension.
Hexamethonium bromide has been used:
- as an autonomic ganglia-blocking agent to study its effects on whisker movement in rats
- as a nicotinic receptor antagonist to study its effects on antigen-induced arthritis (AIA) progression in mice
- as a non-selective ganglionic nicotinic acetylcholine receptor (nAChR) antagonist to study its effects on cytisine-induced autonomic cardiovascular responses in mice
Safety
| Symbol(GHS) |  GHS08 |
| Signal word | Danger |
| Hazard statements | H370 |
| Precautionary statements | P501-P260-P270-P264-P308+P311-P405 |
| Safety Statements | 22-24/25 |
| WGK Germany | 2 |
| RTECS | BQ8575000 |
| TSCA | Yes |
| HS Code | 29239000 |
