3-Hydroxy-3-methylpentane-1，5-dioic Acid , ≥93.0% , 503-49-1

Synonym(s):
3-Hydroxy-3-methylpentanedioic acid

CAS NO.：503-49-1

Empirical Formula: C6H10O5

Molecular Weight: 162.14

MDL number: MFCD00002712

EINECS: 207-971-1

PRODUCT Properties

• Melting point: 105-108 °C (lit.)
• Boiling point: 120 °C / 13mmHg
• Density: 1.2132 (rough estimate)
• refractive index: 1.4230 (estimate)
• storage temp.: -20°C
• solubility: DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 5 mg/ml; PBS (pH 7.2): 10 mg/ml
• form: powder to crystal
• pka: 3.95±0.10(Predicted)
• color: White to Light yellow
• Merck: 14,5808
• BRN: 1769194
• CAS DataBase Reference: 503-49-1(CAS DataBase Reference)

Description and Uses

Meglutol (β-hydroxy-β-methylglutaric acid; HMG) is a hypolipidemic agent that acts via the inhibition of cholesterol synthesis a t the stage of HMG-CoAreductase, blocking the conversion of HMG-CoA to mevalonate. This conversion is the rate-limiting step in cholesterol biosynthesis and is the point of physiological feedback control; as such, it appears to be the ideal locus of action for a hypolipidemic agent. Investigational compounds that act by this mechanism include the natural products compactin and mevinolin.

3-Hydroxy-3-methylpentane-1,5-dioic Acid (cas# 503-49-1) is a compound useful in organic synthesis.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319
• Precautionary statements: P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 22-24/25-36-26
• WGK Germany: 2
• RTECS: MA3753000
• F: 10
• HS Code: 29181990
• Toxicity: LD50 in mice (g/kg): 7.33 orally; 3.23 i.p. (Savoie, Lupien)