2-Hydroxy-3-(trifluoromethyl)pyridine , 98% , 22245-83-6
CAS NO.：22245-83-6
Empirical Formula: C6H4F3NO
Molecular Weight: 163.1
MDL number: MFCD00153194
EINECS: 671-273-7
| Pack Size | Price | Stock | Quantity |
| 1G | RMB24.00 | In Stock |
|
| 5G | RMB39.20 | In Stock |
|
| 25G | RMB6384.00 | In Stock |
|
| 100G | RMB15999.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 150-153°C |
| Boiling point: | 223.7±40.0 °C(Predicted) |
| Density | 1.398±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| form | powder to crystal |
| pka | 9.67±0.10(Predicted) |
| color | White to Almost white |
| InChI | InChI=1S/C6H4F3NO/c7-6(8,9)4-2-1-3-10-5(4)11/h1-3H,(H,10,11) |
| InChIKey | JHDCDEHVUADNKQ-UHFFFAOYSA-N |
| SMILES | C1(=O)NC=CC=C1C(F)(F)F |
| LogP | 0.71 at 25℃ |
Description and Uses
2-hydroxy-3-(trifluoromethyl)pyridine (or 3-(Trifluoromethyl)-2-pyridone) is a trifluoromethyl substituted 2-hydroxypyridine. It is used as a synthesis intermediate for ligands and bioactive ingredients in the application of drug discovery and catalytic reactions. In catalytic reactions, the amide group of 2-pyridone binds to transition metals, forming stable 5-/6-membered ring intermediates. Hence, 2-hydroxy-3-(trifluoromethyl)pyridine is widely used as a ligand in catalytic reactions such as directed C-H activation on meta-position. In addition, the trifluoromethyl substituent of 3-(trifluoromethyl)-2-pyridone tunes its metal-binding affinity and limits the reaction site for improving regioselectivity.
2-Hydroxy-3-trifluoromethylpyridine is a reactant in the synthesis of Pyrido[2,3-b]pyrazine, a TRPV1 antagonist .
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Hazard Codes | Xi,Xn,T |
| Risk Statements | 36/37/38-65-20/21/22-20/21-36-25 |
| Safety Statements | 26-36/37/39-36-45 |
| RIDADR | UN2811 |
| HazardClass | IRRITANT |
| HS Code | 29333990 |
