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A4720212

Hederagenin , Analysis of standard products, ≥98% , 465-99-6

Synonym(s):
3,23-Dihydroxyolean-12-en-28-acid;Astrantiagenin E;Caulosapogenin;Hederagenic acid;Hederagenol

CAS NO.:465-99-6

Empirical Formula: C30H48O4

Molecular Weight: 472.71

MDL number: MFCD00017385

EINECS: 207-369-9

Pack Size Price Stock Quantity
50mg RMB375.20 In Stock
250mg RMB1279.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 332-334°
alpha  D20 +81° (c = 0.7 in pyridine)
Boiling point: 493.44°C (rough estimate)
Density  0.9871 (rough estimate)
refractive index  1.4800 (estimate)
storage temp.  Sealed in dry,2-8°C
solubility  methanol: soluble1mg/mL
pka 4.63±0.70(Predicted)
form  Solid
color  White to Off-White
λmax 405nm(H2SO4)(lit.)
Merck  14,4624
InChIKey PGOYMURMZNDHNS-MYPRUECHSA-N
LogP 7.410 (est)

Description and Uses

Hederagenin is a triterpene saponin that has been found in P. eximia with diverse biological activities. It increases production of reactive oxygen species (ROS), reduces colony formation, and induces apoptosis in cisplatin-resistant head and neck carcinoma (HNC) cells. In vivo, hederagenin (50, 100, and 200 mg/kg) suppresses tumor growth in a cisplatin-resistant HNC mouse xenograft model. It reduces aortic atherosclerotic lesion area, serum cholesterol and LDL levels, and inducible nitric oxide synthase (iNOS) protein levels in a rat model of atherosclerosis. Hederagenin (50 mg/kg) reduces ethanol-induced production of TNF-α, IL-6, and COX-2, alcohol dehydrogenase 2 (ALDH2) mRNA expression, and liver damage in a rat model of alcohol-induced hepatotoxicity. It also induces autophagy and inhibits oligomerization of α-synuclein in a mouse model of Parkinson''s disease induced by MPTP.

Triterpenoid which can inhibit the proliferation of leukemia HL-60 cells.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312+P330-P501
Hazard Codes  Xi
Risk Statements  22
Safety Statements  22-45-24/25
WGK Germany  3
HS Code  29181990

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