Home Categories API Arbidol HCl
A4709331

Arbidol HCl , ≥99% , 131707-23-8

Synonym(s):
6-Bromo-4-((dimethylamino)methyl)-5-hydroxy-1-methyl-2-((phenylthio)methyl)-1H-Indole-3-carboxylic acid ethyl ester monohydrochloride

CAS NO.:131707-23-8

Empirical Formula: C22H26BrClN2O3S

Molecular Weight: 513.875

MDL number: MFCD00344795

EINECS: 680-680-9

Pack Size Price Stock Quantity
200mg RMB55.20 In Stock
250mg RMB79.20 In Stock
1g RMB199.20 In Stock
5g RMB700.80 In Stock
25g RMB2639.20 In Stock
others     Enquire
Update time: 2022-07-08

PRODUCT Properties

Melting point: 133-137?C
storage temp.  -20°C
solubility  DMSO: soluble20mg/mL protein, clear
form  powder
color  white to beige
Stability: Hygroscopic
InChI InChI=1S/C22H25BrN2O3S.ClH/c1-5-28-22(27)20-18(13-29-14-9-7-6-8-10-14)25(4)17-11-16(23)21(26)15(19(17)20)12-24(2)3;/h6-11,26H,5,12-13H2,1-4H3;1H
InChIKey OMZHXQXQJGCSKN-UHFFFAOYSA-N
SMILES C(C1=C(N(C)C2=CC(Br)=C(O)C(CN(C)C)=C12)CSC1C=CC=CC=1)(=O)OCC.Cl
CAS DataBase Reference 131707-23-8(CAS DataBase Reference)

Description and Uses

Umifenovir is a broad-spectrum antiviral agent. It inhibits the replication of H5N1 influenza (IC50 = 30 μg/ml) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vitro (IC50 = 3.537 μM). Umifenovir inhibits entry of hepatitis C virus (HCV) pseudoparticles in Huh7 cells (IC50 = 6 μg/ml) and inhibits Zika virus protein synthesis in Vero cells. In vivo, umifenovir (45 mg/kg) reduces the formation of influenza-induced lung lesions in ferrets.

Arbidol hydrochloride (ARB) is a small monocular compound. It is used to prevent severe pneumonia and virus-associated cytokine dysregulation induced by influenza viruses (IFV). ARB also possesses some immunomodulatory properties, including the effects of interferon induction and macrophage activation.
Arbidol is a broad-spectrum antiviral that has demonstrated activity against a number of enveloped and non-enveloped viruses, and is used clinically to treat influenza. Arbidol inhibits viral entry into host cell and stimulates immune response. Arbidol inhibits fusion between the viral capsid and the cell membrane of the target cell, thus preventing viral entry.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313
Hazard Codes  Xi
Risk Statements  36/38
Safety Statements  26
WGK Germany  3
Toxicity guinea pig,LD50,oral,> 3gm/kg (3000mg/kg),Drugs of the Future. Vol. 17, Pg. 1079, 1992.

RELATED PRODUCTS