4-Hydroxy-TEMPO , 98% , 2226-96-2

Synonym(s):
TEMPOL;4-Hydroxy-TEMPO;4-Hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl;4-Hydroxy-TEMPO, 4-Hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl;4-Hydroxy-2,2,6,6-tetramethylpiperidine 1-oxyl

CAS NO.：2226-96-2

Empirical Formula: C9H18NO2*

Molecular Weight: 172.24

MDL number: MFCD00006478

EINECS: 218-760-9

PRODUCT Properties

• Melting point: 69-71 °C(lit.)
• Boiling point: 302.58°C (rough estimate)
• Density: 1.0402 (rough estimate)
• vapor pressure: 0.025Pa at 20℃
• refractive index: 1.4350 (estimate)
• Flash point: 146°(295°F)
• storage temp.: 2-8°C
• solubility: 1670g/l
• form: Crystals or Crystalline Powder
• pka: 5.07[at 20 ℃]
• color: Orange
• PH: 8.2 (20g/l, H2O, 20℃)
• Water Solubility: soluble
• Merck: 14,9141
• BRN: 1422990
• Stability: Stable. Incompatible with strong oxidizing agents.
• InChIKey: FAPCFNWEPHTUQK-UHFFFAOYSA-N
• LogP: 0.56 at 25℃
• CAS DataBase Reference: 2226-96-2(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperidinyloxy, 4-hydroxy-2,2,6,6-tetramethyl-(2226-96-2)
• EPA Substance Registry System: 1-Piperidinyloxy, 4-hydroxy-2,2,6,6-tetramethyl- (2226-96-2)

Description and Uses

TEMPOL is a piperidine nitroxide and spin label with superoxide dismutase (SOD) mimetic activity. It inhibits lipid peroxidation in rat liver microsomes with 50% inhibition of microsomal lipid peroxidation (IP₅₀) values of 117, 61, and 381 μM for peroxidation induced by iron plus NADPH, iron plus ascorbate, and t-butylhydroperoxide, respectively. TEMPOL (1 mM) inhibits production of superoxide anions by 92% via a xanthine-xanthine oxidase reaction in vitro. It reduces mean arterial pressure and heart rate in spontaneously hypertensive rats (ED₅₀s = 70 and 63 μmol/kg, respectively) when administered intravenously. TEMPOL is a cell-permeable spin label that has been used to quantify intracellular oxygen in various cell types by electron spin resonance (ESR) spectroscopy.

Tempol, a water-soluble piperidine nitroxide derivative having nonspecific radical-scavenging and superoxide dismutase (SOD) activity, protects cultured aerobic, but not hypoxic, cells against radiation-induced killing. Protection does not depend on intracellular thiols and does not involve O2-depletion. Tempol reacts with peroxyl radicals and can also oxidize DNA-bound metal ions, thereby interfering with OH? generation.

Safety

• Symbol(GHS): GHS05,GHS07
• Signal word: Danger
• Hazard statements: H302-H318
• Precautionary statements: P264-P270-P280-P301+P312-P305+P351+P338-P501
• Hazard Codes: Xn,Xi
• Risk Statements: 22-36/37/38-36/38
• Safety Statements: 26-36-37/39-36/37/39-27
• WGK Germany: 1
• RTECS: TN8991000
• TSCA: Yes
• HS Code: 29333999
• Hazardous Substances Data: 2226-96-2(Hazardous Substances Data)
• Toxicity: LD50 oral in rat: 1053mg/kg