3-Hydroxyazetidine Hydrochloride , 97% , 18621-18-6
CAS NO.:18621-18-6
Empirical Formula: C3H8ClNO
Molecular Weight: 109.55
MDL number: MFCD02683887
EINECS: 628-004-3
Pack Size | Price | Stock | Quantity |
250MG | RMB23.20 | In Stock |
|
1G | RMB25.60 | In Stock |
|
5G | RMB31.20 | In Stock |
|
25G | RMB118.40 | In Stock |
|
100G | RMB466.40 | In Stock |
|
others | Enquire |
PRODUCT Properties
Melting point: | 85-90 °C |
storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
form | Solid |
color | White to Off-White |
Water Solubility | Soluble in water, DMSO, methanol. |
Sensitive | Hygroscopic |
Stability: | Hygroscopic |
InChI | InChI=1S/C3H7NO.ClH/c5-3-1-4-2-3;/h3-5H,1-2H2;1H |
InChIKey | UQUPQEUNHVVNKW-UHFFFAOYSA-N |
SMILES | C1(O)CNC1.Cl |
CAS DataBase Reference | 18621-18-6(CAS DataBase Reference) |
Description and Uses
3-hydroxyazaecyclobutane hydrochloride is an azaecyclobutane compound that is an important intermediate in the synthesis of Brectinib, which is obtained through a multi-step reaction. Brectinib was approved by the European Union. The monotherapy or in combination with methotrexate for the treatment of adult patients with moderate to severe active rheumatoid arthritis with inadequate or intolerant relief from one or more antirheumatic drugs. It is also the first JAK inhibitor approved in the European Union for the treatment of rheumatoid arthritis.
3-Hydroxyazetidine hydrochloride is an building block used in a recent synthesis of a fluoroquinolone antibiotic and a useful intermediate in the synthesis of polypeptides.
Safety
Symbol(GHS) | GHS05,GHS07 |
Signal word | Danger |
Hazard statements | H302-H315-H318-H335 |
Precautionary statements | P280-P301+P312+P330-P302+P352-P305+P351+P338+P310 |
Hazard Codes | C,Xi,Xn |
Risk Statements | 36/37/38-41-37/38-22 |
Safety Statements | 26-36/37/39 |
RIDADR | UN1759 |
WGK Germany | 3 |
Hazard Note | Harmful/Corrosive |
HazardClass | IRRITANT |
HS Code | 29339900 |