Glyoxylic acid solution , 50%water solution , 298-12-4

Synonym(s):
Formylformic acid;Oxoethanoic acid

CAS NO.：298-12-4

Empirical Formula: C2H2O3

Molecular Weight: 74.04

MDL number: MFCD00006958

EINECS: 206-058-5

PRODUCT Properties

• Melting point: -93°C
• Boiling point: 111°C
• Density: 1.33 g/mL at 20 °C
• vapor pressure: 14hPa at 19.85℃
• refractive index: n20/D 1.414
• Flash point: 111°C
• storage temp.: Store below +30°C.
• solubility: Miscible with ethanol. Slightly miscible with ether and benzene. Immiscible with esters.
• pka: 3.18(at 25℃)
• form: clear liquid
• color: Colorless to Light orange to Yellow
• Water Solubility: miscible
• Merck: 14,4511
• BRN: 741891
• InChIKey: HHLFWLYXYJOTON-UHFFFAOYSA-N
• LogP: -0.930 (est)
• CAS DataBase Reference: 298-12-4(CAS DataBase Reference)
• NIST Chemistry Reference: Acetic acid, oxo-(298-12-4)
• EPA Substance Registry System: Acetic acid, 2-oxo- (298-12-4)

Description and Uses

Glyoxalic acid can be used in the synthesis of a variety of reactions.
Glyoxylic acid is used in Hopkins Cole reaction, which is used in the detection of tryptophan in proteins.
It reacts with phenol to get 4-hydroxymandelic acid, which on further reaction with ammonia gives hydroxyphenylglycine, as a precursor to the drug amoxicillin.
It is also used as a starting material for the preparation of 4-hydroxyphenylacetic acid, which is used to get atenolol.

Safety

• Symbol(GHS): GHS05,GHS07
• Signal word: Danger
• Hazard statements: H290-H317-H318
• Precautionary statements: P234-P261-P272-P280-P302+P352-P305+P351+P338
• Hazard Codes: C,Xi
• Risk Statements: 34-43-41
• Safety Statements: 26-36/37/39-45-37/39-24
• RIDADR: UN 3265 8/PG 2
• WGK Germany: 1
• RTECS: MD4550000
• TSCA: Yes
• HazardClass: 8
• PackingGroup: III
• HS Code: 29183000
• Hazardous Substances Data: 298-12-4(Hazardous Substances Data)
• Toxicity: rat,LDLo,intramuscular,250mg/kg (250mg/kg),Bolletino della Societe Italiana di Biologia Sperimentale. Vol. 36, Pg. 1937, 1960.