Ginsenoside Rg3 , ≥98%(HPLC) , 14197-60-5

Synonym(s):
(3β,12β)-12,20-Dihydroxydammar-24-en-3-yl 2-O-β-D-glucopyranosyl-β-D-glucopyranoside;20(S)-Ginsenoside-Rg3;Rg3

CAS NO.：14197-60-5

Empirical Formula: C42H72O13

Molecular Weight: 785.03

MDL number: MFCD06410950

PRODUCT Properties

• Melting point: 315-318°C
• Boiling point: 885.0±65.0 °C(Predicted)
• Density: 1.30
• storage temp.: 2-8°C
• solubility: DMSO: ≥5mg/mL
• pka: 12.85±0.70(Predicted)
• form: powder
• color: white to beige
• optical activity: [α]/D +10 to +20°, c = 1 in methanol
• InChIKey: RWXIFXNRCLMQCD-JBVRGBGGSA-N
• CAS DataBase Reference: 14197-60-5(CAS DataBase Reference)

Description and Uses

Ginsenosides are pharmacologically active natural constituents of ginseng and other plants of the genus Panax. Structurally, they are steroid glycosides derived from the triterpene squalene. Ginsenoside Rg₃ is a panaxadiol found in white and red P. ginseng. This ginsenoside has diverse in vitro and in vivo effects, including anti-cancer, neuroprotective, anti-hypertensive, and anti-inflammatory actions. Ginsenoside Rg₃ induces apoptosis and inhibits angiogenesis in a variety of cancer models. Notably, this ginsenoside can be produced by heating other ginsenosides, leading to elevated levels in steamed or dried ginseng preparations.

Ginsenoside Rg3 shows a synergistic antitumor effect with cisplatin in cisplatin-resistant bladder tumor cell lines and is considered to be an anti-tumor agent.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302
• Precautionary statements: P301+P312+P330
• Hazard Codes: Xn
• Risk Statements: 22
• WGK Germany: 3
• RTECS: LY9537300
• HS Code: 29389090
• Toxicity: mouse,LD50,intraperitoneal,1250mg/kg (1250mg/kg),Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 343, 1975.