Guaifenesin , ≥98% , 93-14-1

Synonym(s):
3-(o-Methoxyphenoxy)-1,2-propanediol;Glycerol guaiacolate;Guaiacol glyceryl ether;Guaifenesin

CAS NO.：93-14-1

Empirical Formula: C10H14O4

Molecular Weight: 198.22

MDL number: MFCD00016873

EINECS: 202-222-5

PRODUCT Properties

• Melting point: 77-81 °C
• Boiling point: 215 °C (19 mmHg)
• Density: 1.1825 (rough estimate)
• refractive index: 1.5550 (estimate)
• Flash point: 215°C/19mm
• storage temp.: 2-8°C
• solubility: 50g/l (experimental)
• pka: 13.53±0.20(Predicted)
• form: Solid
• color: White to Off-White
• Water Solubility: 5 g/100 mL (25 ºC)
• Merck: 14,4555
• BRN: 2049375
• InChIKey: HSRJKNPTNIJEKV-UHFFFAOYSA-N
• LogP: 1.390

Description and Uses

Guaifenesin is an oral expectorant drug. The expectorant action of guaifenesin is mediated by stimulation of the gastrointestinal tract. It is a common ingredient in prescription and over-the-counter medications used to treat cough due to colds and minor upper respiratory infections. Additionally, Guaifenesin is also a centrally-acting muscle relaxant and is used routinely in combination with analgesics and sedatives in large-animal veterinary surgery.

Guaifenesin is a muscle relaxant with expectorant properties often used as an expectorant to facilitate the removal of phlegm from the airways in acute respiratory tract infections. Guaifenesin comes in tablet and capsule form, as syrup, as dissolving granules, and recently as an extended-release (longacting) tablet. The tablets, capsules, dissolving granules, and syrup are usually taken with or without food every 4 h as needed. The extended-release tablet is usually taken with or without food every 12 h.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302
• Precautionary statements: P264-P270-P301+P312-P501
• Hazard Codes: Xn
• Risk Statements: 22-36/37/38
• Safety Statements: 26-36
• WGK Germany: 1
• RTECS: TY8400000
• Hazard Note: Harmful
• TSCA: Yes
• HS Code: 29093090
• Toxicity: LD50 oral in rabbit: 2553mg/kg