(-)-trans-Caryophyllene , ≥98% , 87-44-5
Synonym(s):
β-Caryophyllene;(−)-trans-Caryophyllene;trans-(1R,9S)-8-Methylene-4,11,11-trimethylbicyclo[7.2.0]undec-4-ene
CAS NO.：87-44-5
Empirical Formula: C15H24
Molecular Weight: 204.35
MDL number: MFCD00075925
EINECS: 201-746-1
| Pack Size | Price | Stock | Quantity |
| 5ml | RMB24.00 | In Stock |
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| 25ml | RMB31.20 | In Stock |
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| 100ml | RMB68.80 | In Stock |
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| 500ml | RMB244.80 | In Stock |
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| 1ml | RMB396.00 | In Stock |
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| 1L | RMB468.00 | In Stock |
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| others | Enquire |
PRODUCT Properties
| Melting point: | <25℃ |
| alpha | D -8 to -9° (chloroform) |
| Boiling point: | 129-130 °C/14 mmHg (lit.) |
| Density | 0.901 g/mL at 25 °C (lit.) |
| vapor pressure | 6Pa at 20℃ |
| FEMA | 2252 | BETA-CARYOPHYLLENE |
| refractive index | n |
| Flash point: | 205 °F |
| storage temp. | -20°C |
| solubility | Chloroform (Sparingly), DMSO (Slightly), Methanol (Slightly) |
| form | Liquid |
| color | Colourless |
| Specific Gravity | 0.90 |
| Odor | at 100.00 %. sweet woody spice clove dry |
| Odor Type | spicy |
| optical activity | [α]23/D 7.5°, neat |
| Water Solubility | 88μg/L at 20℃ |
| JECFA Number | 1324 |
| Merck | 14,1875 |
| BRN | 2044564 |
| Stability: | Light Sensitive |
| LogP | 6.23 at 25℃ |
Description and Uses
β-Caryophyllene (Item No. 21572) is a sesquiterpene that has been found in plants, including C. sativa, C. indica, and hemp, and has diverse biological activities, including lipid metabolic, antioxidant, anti-neuroinflammatory, anti-proliferative, and antinociceptive properties. It is an agonist of the cannabinoid (CB) receptor CB2 (Ki = 155 nM) that inhibits cAMP production induced by forskolin in CHO-K1 cells expressing CB2 receptors (EC50 = 38 nM). β-Caryophyllene is also an agonist of peroxisome proliferator-activated receptor α (PPARα; EC50 = 9.58 μM in a reporter assay). β-Caryophyllene (1 and 2.5 μM) reduces the production of reactive oxygen species (ROS) in and protects against cytotoxicity of SH-SY5Y cells induced by 1-methyl-4-pheylpyridinium (MPP+). It also decreases the β-amyloid burden in the hippocampus and cerebral cortex and improves memory in an APP/PS1 transgenic mouse model of Alzheimer’s disease, decreasing the latency to find the platform in the Morris water maze during training and increasing the time spent in the target quadrant during testing when administered at a dose of 48 mg/kg per day. β-Caryophyllene (50 mg/kg) increases the number of entries into and the time spent in the open arms of the elevated plus maze and the time spent immobile in the forced swim test, indicating anxiolytic-like and antidepressant-like activity, effects that can be blocked by the CB2 receptor antagonist AM630 .
β-Caryophyllene is notable for having a cyclobutane ring, a rarity in nature. β-Caryophyllene is one of the chemical compounds that contributes to the spiciness of black pepper. β-Caryophyllene was shown to selectively bind to the cannabinoid receptor type-2 (CB2) and to exert significant cannabimimetic antiinflammatory effects in mice.
Safety
| Symbol(GHS) |   GHS07,GHS08 |
| Signal word | Danger |
| Hazard statements | H304-H317 |
| Precautionary statements | P261-P272-P280-P301+P310-P302+P352-P331 |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36-24/25 |
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution |
| WGK Germany | 1 |
| RTECS | DT8400000 |
| HS Code | 29021990 |
