Galanthamine hydrobromide from Lycoris sp. , 98% , 1953-04-4

Synonym(s):
Galantamine hydrobromide;Galanthamine hydrobromide

CAS NO.：1953-04-4

Empirical Formula: C17H22BrNO3

Molecular Weight: 368.27

MDL number: MFCD00067672

EINECS: 217-780-5

PRODUCT Properties

• Melting point: 256 °C
• alpha: D20 -93.1° (c = 0.1015 in 15 ml H2O)
• refractive index: -95 ° (C=1.4, H2O)
• storage temp.: Inert atmosphere,Store in freezer, under -20°C
• solubility: Sparingly soluble in water, very slightly soluble in anhydrous ethanol. It dissolves in dilute solutions of alkali hydroxides.
• form: White to off-white crystalline solid.
• color: White to Orange to Green
• Water Solubility: Soluble in water or DMSO
• Merck: 14,4340
• InChI: InChI=1/C17H21NO3.BrH/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17;/h3-6,12,14,19H,7-10H2,1-2H3;1H/t12-,14-,17-;/s3
• InChIKey: QORVDGQLPPAFRS-ORFATOSYNA-N
• SMILES: [C@@]123CCN(C)CC4=CC=C(OC)C(O[C@H]1C[C@@H](O)C=C2)=C34.Br |&1:0,14,16,r|
• LogP: 1.750 (est)

Description and Uses

Galantamine hydrobromide (marketed as Reminyl) is one of a group of three drugs for people with Alzheimer's disease called cholinesterase inhibitors. The other two are called donepezil hydrochloride (common brand name Aricept) and rivastigmine (common brand name Exelon). It is a selective acetylcholinesterase inhibitor that for the treatment and prevention of Alzheimer's disease and other diseases resulting from reduced neuronal metabolism.

Safety

• Symbol(GHS): GHS06
• Signal word: Danger
• Hazard statements: H301
• Precautionary statements: P264-P270-P301+P310-P405-P501
• Hazard Codes: T
• Risk Statements: 25
• Safety Statements: 45-36/37/39-22
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• RTECS: DF8075000
• HazardClass: 6.1
• PackingGroup: II
• HS Code: 29399990
• Toxicity: LD50 i.v. in mice (mg/kg): 5.2 ± 0.2 (Friess)