Home Categories Inorganic chemistry G 418 disulfate salt
A4622312

G 418 disulfate salt , potency:≥650μgpermg , 108321-42-2

Synonym(s):
;, NMD Inhibitor I;neomycin;NMD Inhibitor I

CAS NO.:108321-42-2

Empirical Formula: C20H42N4O14S

Molecular Weight: 594.63

MDL number: MFCD05664725

EINECS: 600-864-4

Pack Size Price Stock Quantity
250MG RMB79.20 In Stock
1G RMB255.20 In Stock
5G RMB1023.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

storage temp.  2-8°C
solubility  H2O: 50 mg/mL
form  white powder
color  white to off-white
optical activity [α]/D (Specific Rotation: +104.4o (c=0.3% in H2O at 26oC))
Water Solubility  soluble
Stability: Hygroscopic
InChIKey QNQZPJLBGRQFDD-ZLRXUJDMSA-N

Description and Uses

Geneticin (also known as G418, G418 sulfate) is an aminoglycoside antibiotic similar in structure to gentamicin B1, produced by Micromonospora rhodorangea. Geneticin blocks polypeptide synthesis by inhibiting the elongation step in both prokaryotic and eukaryotic cells and is commonly used in laboratory research to select genetically engineered cells. Resistance to Geneticin is conferred by the neo gene from Tn5 encoding an aminoglycoside 3'-phosphotransferase, APH 3'II.

Geneticin is an aminoglycoside antibiotic similar in structure to gentamicin used for selection and maintenance of prokaryotic and eukaryotic cells. Optimal concentrations for selection and maintenance vary by cell lines. Bacteria and algae require 5 μg/mL or less while animal cells may require 300-500 μg/mL. It is also used to membrane-permeant allosteric effector of hemoglobin therapeutic in cardiovascular diseases and cancer.

Safety

Symbol(GHS) 
GHS08
Signal word  Danger
Hazard statements  H317-H334
Precautionary statements  P261-P272-P280-P284-P302+P352-P333+P313
Hazard Codes  Xn,Xi
Risk Statements  20/21/22-36/37/38-42/43
Safety Statements  22-24/25-36/37-23-36-26-45
WGK Germany  3
RTECS  CB9378500
HS Code  29419090

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