Ginsenoside Rg3 , Analysis of standards,> 98% , 14197-60-5

Synonym(s):
(3β,12β)-12,20-Dihydroxydammar-24-en-3-yl 2-O-β-D-glucopyranosyl-β-D-glucopyranoside;20(S)-Ginsenoside-Rg3;Rg3

CAS NO.：14197-60-5

Empirical Formula: C42H72O13

Molecular Weight: 785.03

MDL number: MFCD06410950

PRODUCT Properties

• Melting point: 315-318°C
• Boiling point: 885.0±65.0 °C(Predicted)
• Density: 1.30
• storage temp.: 2-8°C
• solubility: DMSO: ≥5mg/mL
• pka: 12.85±0.70(Predicted)
• form: powder
• color: white to beige
• optical activity: [α]/D +10 to +20°, c = 1 in methanol
• InChIKey: RWXIFXNRCLMQCD-JBVRGBGGSA-N

Description and Uses

Ginsenosides are pharmacologically active natural constituents of ginseng and other plants of the genus Panax. Structurally, they are steroid glycosides derived from the triterpene squalene. Ginsenoside Rg₃ is a panaxadiol found in white and red P. ginseng. This ginsenoside has diverse in vitro and in vivo effects, including anti-cancer, neuroprotective, anti-hypertensive, and anti-inflammatory actions. Ginsenoside Rg₃ induces apoptosis and inhibits angiogenesis in a variety of cancer models. Notably, this ginsenoside can be produced by heating other ginsenosides, leading to elevated levels in steamed or dried ginseng preparations.

Ginsenoside Rg3 shows a synergistic antitumor effect with cisplatin in cisplatin-resistant bladder tumor cell lines and is considered to be an anti-tumor agent.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302
• Precautionary statements: P301+P312+P330
• Hazard Codes: Xn
• Risk Statements: 22
• WGK Germany: 3
• RTECS: LY9537300
• HS Code: 29389090
• Toxicity: mouse,LD50,intraperitoneal,1250mg/kg (1250mg/kg),Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 343, 1975.