Genistein , 97% , 446-72-0

Synonym(s):
4ʹ,5,7-Trihydroxyisoflavone;4′,5,7-Trihydroxyisoflavone;5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one;Genistein;Genistein, Soybean - CAS 446-72-0 - Calbiochem

CAS NO.：446-72-0

Empirical Formula: C15H10O5

Molecular Weight: 270.24

MDL number: MFCD00016952

EINECS: 207-174-9

PRODUCT Properties

• Melting point: 297-298 °C
• Boiling point: 333.35°C (rough estimate)
• Density: 1.2319 (rough estimate)
• refractive index: 1.6000 (estimate)
• storage temp.: -20°C
• solubility: DMSO: soluble
• form: powder
• pka: 6.51±0.20(Predicted)
• color: off-white
• Water Solubility: insoluble
• Merck: 14,4391
• BRN: 263823
• Stability: Light Sensitive
• InChIKey: TZBJGXHYKVUXJN-UHFFFAOYSA-N
• LogP: 3.114 (est)

Description and Uses

Genistein (446-72-0) is a naturally occurring flavonoid with a wide range of biological actions. Inhibits protein tyrosine kinases including epidermal growth factor receptor kinase.1,2?Phytoestrogen3?and agonist at GPR304. Displays cancer chemopreventive activity.5

Exhibits specific inhibitory activity against tyrosine kinases,including autophosphorylation of epidermal growth factor receptor kinase (IC50 - 2.6uM). Also inhibits other protein kinases through competitive inhibition of ATP. Inhibits tumor cell proliferation and induces tumor cell differentiation. Produces cell-cycle arrest and apoptosis in Jurat T-leukemia cells. However, it prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Genistein also inhibits topoisomerase II activity in vitro. Genistein has also been shown to inhibit the action of GABA on recombinant GABAA receptors 2. uv(max)ethanol: 262.5 nm (e= 138). moderately sol. in hot alcohol

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302
• Precautionary statements: P264-P270-P301+P312-P501
• Hazard Codes: Xi,Xn
• Risk Statements: 36/38-22
• Safety Statements: 26-24/25-22
• WGK Germany: 3
• RTECS: NR2392000
• TSCA: Yes
• HazardClass: IRRITANT
• HS Code: 29329990