Home Categories Biochemical Engineering Genistein
A4614612

Genistein , Analysis of standard products, ≥98% , 446-72-0

Synonym(s):
4ʹ,5,7-Trihydroxyisoflavone;4′,5,7-Trihydroxyisoflavone;5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one;Genistein;Genistein, Soybean - CAS 446-72-0 - Calbiochem

CAS NO.:446-72-0

Empirical Formula: C15H10O5

Molecular Weight: 270.24

MDL number: MFCD00016952

EINECS: 207-174-9

Pack Size Price Stock Quantity
20MG RMB65.60 In Stock
1g RMB1207.20 In Stock
5g RMB3679.20 In Stock
others     Enquire
Update time: 2022-07-08

PRODUCT Properties

Melting point: 297-298 °C
Boiling point: 333.35°C (rough estimate)
Density  1.2319 (rough estimate)
refractive index  1.6000 (estimate)
storage temp.  -20°C
solubility  DMSO: soluble
form  powder
pka 6.51±0.20(Predicted)
color  off-white
Water Solubility  insoluble
Merck  14,4391
BRN  263823
Stability: Light Sensitive
InChIKey TZBJGXHYKVUXJN-UHFFFAOYSA-N
LogP 3.114 (est)

Description and Uses

Genistein (446-72-0) is a naturally occurring flavonoid with a wide range of biological actions. Inhibits protein tyrosine kinases including epidermal growth factor receptor kinase.1,2?Phytoestrogen3?and agonist at GPR304. Displays cancer chemopreventive activity.5

Exhibits specific inhibitory activity against tyrosine kinases,including autophosphorylation of epidermal growth factor receptor kinase (IC50 - 2.6uM). Also inhibits other protein kinases through competitive inhibition of ATP. Inhibits tumor cell proliferation and induces tumor cell differentiation. Produces cell-cycle arrest and apoptosis in Jurat T-leukemia cells. However, it prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Genistein also inhibits topoisomerase II activity in vitro. Genistein has also been shown to inhibit the action of GABA on recombinant GABAA receptors 2. uv(max)ethanol: 262.5 nm (e= 138). moderately sol. in hot alcohol

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P501
Hazard Codes  Xi,Xn
Risk Statements  36/38-22
Safety Statements  26-24/25-22
WGK Germany  3
RTECS  NR2392000
TSCA  Yes
HazardClass  IRRITANT
HS Code  29329990

RELATED PRODUCTS