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A4607112

Griseofulvin , 97% , 126-07-8

Synonym(s):
(2S)-trans-7-Chloro-2′,4,6-trimethoxy-6′-methylspiro(benzofuran-2[3H],1′-[2]cyclohexene)-3,4′-dione;Griseofulvin

CAS NO.:126-07-8

Empirical Formula: C17H17ClO6

Molecular Weight: 352.77

MDL number: MFCD00082343

EINECS: 204-767-4

Pack Size Price Stock Quantity
5G RMB36.00 In Stock
25G RMB128.00 In Stock
100G RMB301.60 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 218-220 °C(lit.)
Boiling point: 469.04°C (rough estimate)
alpha  354 º (c=1, dimethylform)
Density  1.2579 (rough estimate)
refractive index  1.4429 (estimate)
storage temp.  2-8°C
solubility  Practically insoluble in water, freely soluble in dimethylformamide and in tetrachloroethane, slightly soluble in anhydrous ethanol and in methanol
form  Powder
color  White to yellow-white
Water Solubility  practically insoluble
λmax 321nm(CHCl3)(lit.)
Merck  14,4549
BRN  95226
BCS Class 2 (CLogP), 4 (LogP)
Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO, ethanol, or DMF may be stored at -20° for up to 3 months.
InChIKey DDUHZTYCFQRHIY-RBHXEPJQSA-N
LogP 2.180
CAS DataBase Reference 126-07-8(CAS DataBase Reference)
IARC 2B (Vol. Sup 7, 79) 2001
NIST Chemistry Reference Griseofulvin(126-07-8)
EPA Substance Registry System Griseofulvin (126-07-8)

Description and Uses

Griseofulvin (126-07-8) is an antifungal antimitotic agent. Induces apoptosis of human germ cell tumor cells via disruption of connexin 43/tubulin association concomitant with enhanced translocation of connexin 43 from the cytoplasm to the nucleus.1?Inhibits the growth of adrenocortical cancer cells?in vitro.2 Griseofulvin inhibits centrosome clustering, induces spindle multipolarity, mitotic arrest and cell death in multiple tumor cell lines but not in diploid fibroblasts and keratinocytes with normal centrosome content.3

An antifungal and antiproliferative agent that affects microtubules.

Safety

Symbol(GHS) 
GHS07,GHS08
Signal word  Danger
Hazard statements  H317-H351-H360FD
Precautionary statements  P202-P261-P272-P280-P302+P352-P308+P313
Hazard Codes  T,Xn
Risk Statements  60-61-40-43-45
Safety Statements  53-22-36/37/39-45
RIDADR  UN 1648 3 / PGII
WGK Germany  3
RTECS  WG9800000
HS Code  29419090
Hazardous Substances Data 126-07-8(Hazardous Substances Data)
Toxicity LD50 oral in rat: > 10gm/kg

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