Griseofulvin , 97% , 126-07-8

Synonym(s):
(2S)-trans-7-Chloro-2′,4,6-trimethoxy-6′-methylspiro(benzofuran-2[3H],1′-[2]cyclohexene)-3,4′-dione;Griseofulvin

CAS NO.：126-07-8

Empirical Formula: C17H17ClO6

Molecular Weight: 352.77

MDL number: MFCD00082343

EINECS: 204-767-4

PRODUCT Properties

• Melting point: 218-220 °C(lit.)
• Boiling point: 469.04°C (rough estimate)
• alpha: 354 º (c=1, dimethylform)
• Density: 1.2579 (rough estimate)
• refractive index: 1.4429 (estimate)
• storage temp.: 2-8°C
• solubility: Practically insoluble in water, freely soluble in dimethylformamide and in tetrachloroethane, slightly soluble in anhydrous ethanol and in methanol
• form: Powder
• color: White to yellow-white
• Water Solubility: practically insoluble
• λmax: 321nm(CHCl3)(lit.)
• Merck: 14,4549
• BRN: 95226
• BCS Class: 2 (CLogP), 4 (LogP)
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO, ethanol, or DMF may be stored at -20° for up to 3 months.
• InChIKey: DDUHZTYCFQRHIY-RBHXEPJQSA-N
• LogP: 2.180

Description and Uses

Griseofulvin (126-07-8) is an antifungal antimitotic agent. Induces apoptosis of human germ cell tumor cells via disruption of connexin 43/tubulin association concomitant with enhanced translocation of connexin 43 from the cytoplasm to the nucleus.1?Inhibits the growth of adrenocortical cancer cells?in vitro.2 Griseofulvin inhibits centrosome clustering, induces spindle multipolarity, mitotic arrest and cell death in multiple tumor cell lines but not in diploid fibroblasts and keratinocytes with normal centrosome content.3

An antifungal and antiproliferative agent that affects microtubules.

Safety

• Symbol(GHS): GHS07,GHS08
• Signal word: Danger
• Hazard statements: H317-H351-H360FD
• Precautionary statements: P202-P261-P272-P280-P302+P352-P308+P313
• Hazard Codes: T,Xn
• Risk Statements: 60-61-40-43-45
• Safety Statements: 53-22-36/37/39-45
• RIDADR: UN 1648 3 / PGII
• WGK Germany: 3
• RTECS: WG9800000
• HS Code: 29419090
• Toxicity: LD50 oral in rat: > 10gm/kg