Isoalantolactone , 98% , 470-17-7

CAS NO.：470-17-7

Empirical Formula: C15H20O2

Molecular Weight: 232.32

MDL number: MFCD00056777

PRODUCT Properties

• Melting point: 115℃
• Boiling point: 364.9±42.0 °C(Predicted)
• Density: 1.07±0.1 g/cm3(Predicted)
• storage temp.: 2-8°C
• solubility: Soluble in DMSO (up to 50 mg/ml) or ethanol (30 mg/ml)
• form: solid
• color: White
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
• LogP: 3.420

Description and Uses

Isohelenin (470-17-7) is a sesquiterpene lactone isolated from Mexican Indian medicinal plants known to have anti-inflammatory properties. A potent inhibitor of NFkB (complete inhibition at 5 μM)1 acting via inhibition of IKK?6. Isohelenin-mediated NFkB inhibition suppresses IL-8 expression2, iNOS expression3 and RANTES biosynthesis4. Displays protective effects in endotoxic shock in rodent models.5 Induces apoptosis in glioma cells.6

Isoalantolactone is a sesquiterpene lactone used in the treatment of cancer. It can inhibit tumor cell growth and induce apoptosis.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H317
• Precautionary statements: P261-P272-P280-P302+P352-P333+P313-P321-P363-P501
• Hazard Codes: Xn
• Risk Statements: 40
• Safety Statements: 22-36
• HS Code: 29322090