Flutamide , >98.0%(GC) , 13311-84-7

Synonym(s):
2-Methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide;Flutamide

CAS NO.：13311-84-7

Empirical Formula: C11H11F3N2O3

Molecular Weight: 276.21

MDL number: MFCD00072009

EINECS: 236-341-9

PRODUCT Properties

• Melting point: 112 °C
• Boiling point: 400.3±45.0 °C(Predicted)
• Density: 1.3649 (estimate)
• storage temp.: 2-8°C
• solubility: Practically insoluble in water, freely soluble in acetone and in ethanol (96 per cent).
• pka: 13.12±0.70(Predicted)
• form: Solid
• color: Pale Yellow to Light Yellow
• Merck: 14,4208
• InChI: InChI=1S/C11H11F3N2O3/c1-6(2)10(17)15-7-3-4-9(16(18)19)8(5-7)11(12,13)14/h3-6H,1-2H3,(H,15,17)
• InChIKey: MKXKFYHWDHIYRV-UHFFFAOYSA-N
• SMILES: C(NC1=CC=C([N+]([O-])=O)C(C(F)(F)F)=C1)(=O)C(C)C

Description and Uses

Flutamide is an orally active, non-steroidal antiandrogen indicated for the treatment of prostatic cancer in both castrates and noncastrates.

Besides prostate cancer, flutamide has also been tested and/or used off-label in other hyperandrogenism-related disorders like benign prostatic hyperplasia, acne vulgaris, and hirsutism syndrome. Due to its teratogenic potential, flutamide is restricted for premenopausal women and used only in combination with effective contraception.

Safety

• Symbol(GHS): GHS07,GHS08,GHS09
• Signal word: Warning
• Hazard statements: H302-H351-H361-H373-H411
• Precautionary statements: P202-P260-P264-P273-P301+P312-P308+P313
• Hazard Codes: Xn,Xi
• Risk Statements: 20/21/22-63-36/37/38
• Safety Statements: 22-36-36/37/39-27-26
• WGK Germany: 3
• RTECS: UG5700000
• HS Code: 29242990