Formononetin , 98% , 485-72-3

Synonym(s):
Formonetin;Formononetol;7-Hydroxy-3-(4?-methoxyphenyl)-4H-benzopyran-4-one;7-Hydroxy-3-(4-methoxyphenyl)-4H-1-benzopyran-4-one;7-Hydroxy-3-(4-methoxyphenyl)chromone

CAS NO.：485-72-3

Empirical Formula: C16H12O4

Molecular Weight: 268.26

MDL number: MFCD00016948

EINECS: 207-623-9

PRODUCT Properties

• Melting point: 256-260 °C
• Boiling point: 331.43°C (rough estimate)
• Density: 1.1529 (rough estimate)
• vapor pressure: 0Pa at 25℃
• refractive index: 1.4350 (estimate)
• storage temp.: 2-8°C
• solubility: Soluble in DMSO (up to 100 mg/ml).
• form: Powder
• pka: 6.99±0.20(Predicted)
• color: White to light beige
• λmax: 300nm(EtOH)(lit.)
• Merck: 14,4244
• BRN: 237979
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
• InChIKey: HKQYGTCOTHHOMP-UHFFFAOYSA-N
• LogP: 1.7 at 25℃
• CAS DataBase Reference: 485-72-3(CAS DataBase Reference)
• EPA Substance Registry System: 4H-1-Benzopyran-4-one, 7-hydroxy-3-(4-methoxyphenyl)- (485-72-3)

Description and Uses

Formononetin (485-72-3) is a naturally occurring isoflavone isolated from Astragalus and other plants. Increases adipocyte thermogenesis by modulating PPARγ activity.1?Activates AMP-activated protein kinase/β-catenin signaling to inhibit adipogenesis.2?Accelerates wound repair by increasing expression of Egr-1 transcription factor.3?Potential cancer chemopreventive and chemotherapeutic.4?Provides neuroprotection against traumatic brain injury by inhibition of neuroinflammation in a rat model.5

An isoflavone found in a variety of plants. When metabolized in the rumen this compound transforms into a potent estrogen.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319
• Precautionary statements: P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 37/39-26-36
• WGK Germany: 3
• RTECS: DJ3100114
• HS Code: 29329990