Felbamate , ≥99% , 25451-15-4

Synonym(s):
2-Phenyl-1,3-propanediol dicarbamate

CAS NO.：25451-15-4

Empirical Formula: C11H14N2O4

Molecular Weight: 238.24

MDL number: MFCD00865296

EINECS: 247-001-4

PRODUCT Properties

• Melting point: 148-1500C
• Boiling point: 511.9±50.0 °C(Predicted)
• Density: 1.275±0.06 g/cm3(Predicted)
• Flash point: 9℃
• storage temp.: Keep in dark place,Inert atmosphere,Room temperature
• solubility: alcohol: soluble
• pka: 12.99±0.50(Predicted)
• form: Solid
• color: White
• BCS Class: 2
• CAS DataBase Reference: 25451-15-4(CAS DataBase Reference)
• NIST Chemistry Reference: Felbamate(25451-15-4)

Description and Uses

Felbamate, characterized by its low toxicity and wide margin of safety, is efficacious in treating refractory patients with generalized tonic-clonic and complex partial seizures as monotherapy and adjunctive therapy.It has also been demonstrated to have a neuroprotective effect in cerebral ischemia and hypoxia. It has been suggested that the mechanism of its anticonvulsant activity is possibly through an interaction with the strychnineinsensitive receptor site on the NMDA receptor complex.

Antiepileptic, structurally similar to meprobamate.

Safety

• Symbol(GHS): GHS02,GHS06,GHS08
• Signal word: Danger
• Hazard statements: H225-H301+H311+H331-H370
• Precautionary statements: P210-P260-P280-P301+P310-P311
• RIDADR: UN1230 - class 3 - PG 2 - Methanol
• WGK Germany: 2
• RTECS: TZ1070000
• HS Code: 2924296000
• Hazardous Substances Data: 25451-15-4(Hazardous Substances Data)
• Toxicity: LD50 i.p. in mice: 4000 mg/kg (Ludwig et al.)