Flubendazole , ≥98%(HPLC) , 31430-15-6

Synonym(s):
Flubendazol;Flubendazole;Flumoxanal;Methyl [5-(4-fluorobenzoyl)-1H-benzimidazol-2-yl]carbamate

CAS NO.：31430-15-6

Empirical Formula: C16H12FN3O3

Molecular Weight: 313.28

MDL number: MFCD00871999

EINECS: 250-624-4

PRODUCT Properties

• Melting point: 290°C
• Density: 1.3720 (estimate)
• storage temp.: 2-8°C
• solubility: Practically insoluble in water, in alcohol and in methylene chloride
• pka: 10.66±0.10(Predicted)
• form: Solid
• color: White to Off-White
• Merck: 14,4118

Description and Uses

Flubendazole is a benzimidazole carbamate anthelmintic. It completely eliminates larvae in a mouse model of A. cantonensis infection and exhibits a mean larval reduction of 100% in a T. spiralis infection model when administered at doses of 5 and 50 mg/kg per day, respectively. Flubendazole inhibits mammalian tubulin polymerization (IC₅₀ = 2.5 μM) and inhibits binding of [³H]mebendazole to H. contortus L3 larval tubulin (IC₅₀ = 0.17 μM). Flubendazole also inhibits the proliferation of BT-549, SK-BR-3, MDA-MB-231, and MCF-7 breast cancer cells (IC₅₀s = 0.72, 1.51, 1.75, and 5.51 μM, respectively) and reduces tumor growth in an MDA-MB-231 mouse xenograft model when administered at a dose of 25 mg/kg.

An insectocidal agent.

Safety

• Symbol(GHS): GHS08
• Signal word: Warning
• Hazard statements: H361
• Precautionary statements: P201-P202-P281-P308+P313-P405-P501
• Risk Statements: 22
• Safety Statements: 44
• WGK Germany: 2
• RTECS: DD6497500
• HS Code: 29339900
• Toxicity: LD50 in mice, rats, guinea pigs (mg/kg): >2560 orally (Thienpont)