Famotidine , ≥99% , 76824-35-6

Synonym(s):
{3-[((2-((Aminoiminomethyl)amino)-4-thiazolyl)methyl)thio]-N′-(aminosulfonyl)propaneimidamide};N′-(Aminosulfonyl)-3-([2-(diaminomethyleneamino)-4-thiazolyl]methylthio)propanamidine;Famotidine

CAS NO.：76824-35-6

Empirical Formula: C8H15N7O2S3

Molecular Weight: 337.45

MDL number: MFCD00079297

EINECS: 616-396-9

PRODUCT Properties

• Melting point: 163-164°C
• Boiling point: 562.7±60.0 °C(Predicted)
• Density: 1.5111 (rough estimate)
• refractive index: 1.7400 (estimate)
• storage temp.: 2-8°C
• solubility: Very slightly soluble in water, freely soluble in glacial acetic acid, very slightly soluble in anhydrous ethanol, practically insoluble in ethyl acetate. It dissolves in dilute mineral acids
• pka: pKa 6.76(H2O t=23.0) (Uncertain)
• form: Solid
• color: White to Off-White
• Water Solubility: 1.1 mg/mL
• BCS Class: 3
• Stability: Light Sensitive
• InChI: InChI=1S/C8H15N7O2S3/c9-6(15-20(12,16)17)1-2-18-3-5-4-19-8(13-5)14-7(10)11/h4H,1-3H2,(H2,9,15)(H2,12,16,17)(H4,10,11,13,14)
• InChIKey: XUFQPHANEAPEMJ-UHFFFAOYSA-N
• SMILES: C(NS(N)(=O)=O)(=N)CCSCC1=CSC(NC(N)=N)=N1

Description and Uses

Famotidine is a competitive histamine H2-receptor antagonist, and the main pharmacodynamic effect of famotidine is to cause the inhibition of gastric secretion. Famotidine on decomposition releases toxic products such as carbon oxides (CO, CO2), nitrogen oxides (NO, NO2), and sulphur oxides (SO2, SO3). Famotidine is a medication that is available both in prescription and over-the-counter forms. It is used to treat conditions related to the oesophagus, stomach, and intestines. Some specific famotidine is used for the treatment of duodenal ulcers, gastric ulcers (stomach ulcers), gastroesophageal reflux disease (GERD), and pathological hypersecretory conditions that occur when stomach acid is secreted/ produced in very large quantities, an abnormal health condition called ‘Zollinger-Ellison syndrome’.

For the treatment of peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD).

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H303
• Precautionary statements: P270-P301+P312-P403-P501c
• Hazard Codes: T
• Risk Statements: 20/21/22-45-61
• Safety Statements: 22-24/25-53-45-36/37/39
• WGK Germany: 2
• RTECS: UA2300000
• HS Code: 29341000
• Toxicity: LD50 i.v. in mice: 244.4 mg/kg (Yasufumi)