Flumazenil , >99%(HPLC) , 78755-81-4

Synonym(s):
Flumazenil - CAS 78755-81-4 - Calbiochem;GABA _A Receptor Antagonist, Flumazenil, Ro 15-1788;GABA_A Receptor Antagonist, Flumazenil, Ro 15-1788;Ro 15-1788;Ro15-1788

CAS NO.：78755-81-4

Empirical Formula: C15H14FN3O3

Molecular Weight: 303.29

MDL number: MFCD00242764

EINECS: 616-650-9

PRODUCT Properties

• Melting point: 201-203°C
• Boiling point: 528.0±50.0 °C(Predicted)
• Density: 1.39±0.1 g/cm3(Predicted)
• storage temp.: Sealed in dry,2-8°C
• solubility: Soluble in DMSO to 25mM
• pka: 0.86±0.20(Predicted)
• form: solid
• color: white
• Water Solubility: 128 mg/L
• Merck: 14,4135
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Description and Uses

Flumazenil is a benzodiazepine antagonist useful as a fast-acting antidote in the treatment of benzodiazepine intoxication, and in reversing the central sedative effects of benzodiazepines during anesthesia.

Flumazenil is an imidazodiazepine which selectively blocks the central effects of classic benzodiazepines. It is used as benzodiazepine antagonist sedation reversal drug.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H303
• Precautionary statements: P270-P301+P312-P403-P501c
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-27-36/37/39
• WGK Germany: 2
• RTECS: NI2922170
• HS Code: 2933997500
• Toxicity: LD50 in mice, rats (mg/kg): 4000, 1360 i.p.; 4300, 6000 orally (Hunkeler)