Flumequine , Analysis standard , 42835-25-6
CAS NO.：42835-25-6
Empirical Formula: C14H12FNO3
Molecular Weight: 261.25
MDL number: MFCD00079298
EINECS: 255-962-6
| Pack Size | Price | Stock | Quantity |
| 250MG | RMB310.40 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 253-255°C |
| Boiling point: | 439.7±45.0 °C(Predicted) |
| Density | 1.45±0.1 g/cm3(Predicted) |
| RTECS | DK1672000 |
| Flash point: | >110°(230°F) |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | 1 M NH4OH: soluble50mg/mL |
| pka | pKa 6.42(H2O t=25.0 I=0.025)(Approximate) |
| form | powder |
| color | white to off-white |
| Water Solubility | Soluble in DMSO and dilute alkali hydroxides. Insoluble in water |
| Merck | 14,4137 |
| BRN | 490724 |
| Stability: | Stable. Incompatible with strong oxidizing agents. |
| CAS DataBase Reference | 42835-25-6(CAS DataBase Reference) |
| EPA Substance Registry System | 1H,5H-Benzo[ij]quinolizine-2-carboxylic acid, 9-fluoro-6,7-dihydro-5-methyl-1-oxo- (42835-25-6) |
Description and Uses
Flumequine is a synthetic antibiotic belonging to the second-generation quinolone group and is mainly active against Gram negative bacteria. It is currently the only non-humans shared broad-spectrum antimicrobial veterinary drug. It is taken as the substitute product of norfloxacin. It has a strong bactericidal activity with excellent efficacy in the treatment of animal bacterial diseases. Its main effect is to inhibit bacterial deoxy nucleic acid (DNA) gyrase, interfering with the deoxyribonucleic acid (DNA) synthesis, thereby causing failure of cell for further division, and thus playing the role of killing bacteria. It is used in bovine, ovine, chicken, rabbits, goats, horses and salmonidae, however the establishment of MRLs was only requested for non-lactating cattle, pigs, sheep, chicken and salmonidae.
Flumequine is a fluoroquinolone compound with antimicrobial activity against Gram-negative organisms. It is used in the treatment of enteric infections in food animals and in the treatment of bacterial infections in farmed fish. Flumequine is replacing oxolinic acid in aquaculture because of its more appropriate pharmacokinetic profile and lower effective doses (Treves-Brown 2000). Flumequine also has limited use in humans for the treatment of urinary tract infections.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 22-24/25-36/37/39-27-26 |
| WGK Germany | 3 |
| F | 10 |
| HS Code | 29339900 |
| Hazardous Substances Data | 42835-25-6(Hazardous Substances Data) |
