Fenbendazole , Analysis standard , 43210-67-9

Synonym(s):
Fenbendazole;Fenbendazole Impurity B (PhEur);Methyl (5-chloro-1H-benzimidazol-2-yl)carbamate;Methyl 5-(phenylthio)-2-benzimidazolecarbamate

CAS NO.：43210-67-9

Empirical Formula: C15H13N3O2S

Molecular Weight: 299.35

MDL number: MFCD00144301

EINECS: 256-145-7

PRODUCT Properties

• Melting point: 233°C
• Density: 1.2767 (rough estimate)
• refractive index: 1.6740 (estimate)
• storage temp.: 2-8°C
• Water Solubility: Insoluble in water
• solubility: DMSO:16.67(Max Conc. mg/mL);55.69(Max Conc. mM); DMF:10.0(Max Conc. mg/mL);33.41(Max Conc. mM)
• pka: 10.80±0.10(Predicted)
• form: Solid
• color: White to Light yellow
• Merck: 14,3960
• BRN: 759077
• InChI: InChI=1S/C15H13N3O2S/c1-20-15(19)18-14-16-12-8-7-11(9-13(12)17-14)21-10-5-3-2-4-6-10/h2-9H,1H3,(H2,16,17,18,19)
• InChIKey: HDDSHPAODJUKPD-UHFFFAOYSA-N
• SMILES: C(OC)(=O)NC1NC2=CC(SC3=CC=CC=C3)=CC=C2N=1

Description and Uses

Fenbendazole is a benzimidazole anthelmintic. It is active against Giardia in vitro (IC₅₀ = 0.3 μM). Fenbendazole (20 mg/kg) prevents infiltration of parasites into the brain in a rabbit model of E. cuniculi infection. Fenbendazole also activates HIF-1α and prevents oxidative stress-induced death in primary neurons in vitro.

Fenbendazole is a benzimidazole anthelmintic that is metabolised in mammals to a series of other benzimidazoles including oxfendazole. It is used for the control of gastrointestinal roundworms, lung worms, Nematodes and tape worms. It is the only benzimidazole approved for use in organic livestock production.

Safety

• Symbol(GHS): GHS08,GHS09
• Signal word: Warning
• Hazard statements: H361fd-H373-H410
• Precautionary statements: P201-P202-P260-P273-P280-P308+P313
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-36-24/25
• WGK Germany: 2
• RTECS: DD6520500
• HS Code: 29339900
• Toxicity: dog,LD50,oral,> 500mg/kg (500mg/kg),Pesticide Science. Vol. 8, Pg. 550, 1977.