Fenbendazole , Analysis standard , 43210-67-9
Synonym(s):
Fenbendazole;Fenbendazole Impurity B (PhEur);Methyl (5-chloro-1H-benzimidazol-2-yl)carbamate;Methyl 5-(phenylthio)-2-benzimidazolecarbamate
CAS NO.：43210-67-9
Empirical Formula: C15H13N3O2S
Molecular Weight: 299.35
MDL number: MFCD00144301
EINECS: 256-145-7
| Pack Size | Price | Stock | Quantity |
| 100MG | RMB207.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 233°C |
| Density | 1.2767 (rough estimate) |
| refractive index | 1.6740 (estimate) |
| storage temp. | 2-8°C |
| Water Solubility | Insoluble in water |
| solubility | DMSO:16.67(Max Conc. mg/mL);55.69(Max Conc. mM) DMF:10.0(Max Conc. mg/mL);33.41(Max Conc. mM) |
| pka | 10.80±0.10(Predicted) |
| form | Solid |
| color | White to Light yellow |
| Merck | 14,3960 |
| BRN | 759077 |
| InChI | InChI=1S/C15H13N3O2S/c1-20-15(19)18-14-16-12-8-7-11(9-13(12)17-14)21-10-5-3-2-4-6-10/h2-9H,1H3,(H2,16,17,18,19) |
| InChIKey | HDDSHPAODJUKPD-UHFFFAOYSA-N |
| SMILES | C(OC)(=O)NC1NC2=CC(SC3=CC=CC=C3)=CC=C2N=1 |
| CAS DataBase Reference | 43210-67-9(CAS DataBase Reference) |
| EPA Substance Registry System | Carbamic acid, N-[6-(phenylthio)-1H-benzimidazol-2-yl]-, methyl ester (43210-67-9) |
Description and Uses
Fenbendazole is a benzimidazole anthelmintic. It is active against Giardia in vitro (IC50 = 0.3 μM). Fenbendazole (20 mg/kg) prevents infiltration of parasites into the brain in a rabbit model of E. cuniculi infection. Fenbendazole also activates HIF-1α and prevents oxidative stress-induced death in primary neurons in vitro.
Fenbendazole is a benzimidazole anthelmintic that is metabolised in mammals to a series of other benzimidazoles including oxfendazole. It is used for the control of gastrointestinal roundworms, lung worms, Nematodes and tape worms. It is the only benzimidazole approved for use in organic livestock production.
Safety
| Symbol(GHS) |   GHS08,GHS09 |
| Signal word | Warning |
| Hazard statements | H361fd-H373-H410 |
| Precautionary statements | P201-P202-P260-P273-P280-P308+P313 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36-24/25 |
| WGK Germany | 2 |
| RTECS | DD6520500 |
| HS Code | 29339900 |
| Toxicity | dog,LD50,oral,> 500mg/kg (500mg/kg),Pesticide Science. Vol. 8, Pg. 550, 1977. |
