Ferulic Acid Ethyl Ester , 97% , 4046-02-0

Synonym(s):
Ethyl ferulate

CAS NO.：4046-02-0

Empirical Formula: C12H14O4

Molecular Weight: 222.24

MDL number: MFCD00009190

EINECS: 223-745-5

PRODUCT Properties

• Melting point: 63-65 °C(lit.)
• Boiling point: 164-166 °C0.5 mm Hg(lit.)
• Density: 1.0643 (rough estimate)
• refractive index: 1.4560 (estimate)
• storage temp.: Sealed in dry,Room Temperature
• solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
• form: Solid
• pka: 8.88±0.18(Predicted)
• color: White to Off-White
• Sensitive: Light Sensitive
• BRN: 2696807
• Stability: Hygroscopic, Light Sensitive
• InChIKey: ATJVZXXHKSYELS-FNORWQNLSA-N
• LogP: 1.940 (est)

Description and Uses

Ferulic acid is a hydroxycinnamic acid that is abundant in plants and originally derived from giant fennel (F. communis). This naturally-occurring phenolic has antioxidant activities that provide protection against inflammation and cancer. Ferulic acid ethyl ester is a lipophilic derivative of ferulic acid, demonstrating increased ability to cross cell membranes. Ferulic acid ethyl ester has less antioxidant capacity than ferulic acid in neuronal PC12 cells (IC₅₀ = 66.7 μM for ferulic acid ethyl ester vs. 44.6 μM for ferulic acid, 2,2-diphenyl-1-picrylhydrazyl radical scavenging). However, ferulic acid ethyl ester increases the expression of heme oxygenase-1, Hsp70, and Hsp72, providing neuroprotection against amyloid β-peptide. Moreover, ferulic acid ethyl ester (25 μM) completely prevents cytotoxicity induced by ultraviolet B irradiation of normal human epidermal melanocytes, again associated with an induced expression of heme oxygenase-1 and Hsp70.

Ferulic acid ethyl ester is an ethyl ester derivative of Ferulic acid (F308900), which is used as an antioxidant and food preservative.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P264-P271-P280-P302+P352-P305+P351+P338
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-37/39-36
• WGK Germany: 3
• Hazard Note: Irritant
• HS Code: 29189900