Diazoxide , ≥98% , 364-98-7

Synonym(s):
7-Chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide

CAS NO.：364-98-7

Empirical Formula: C8H7ClN2O2S

Molecular Weight: 230.67

MDL number: MFCD00078578

EINECS: 206-668-1

PRODUCT Properties

• Melting point: >310°C
• Boiling point: 414.8±47.0 °C(Predicted)
• Density: 1.3767 (rough estimate)
• refractive index: 1.6300 (estimate)
• storage temp.: 2-8°C
• solubility: 0.1 M NaOH: soluble
• form: Solid
• pka: pKa 8.5 (Uncertain)
• color: White
• Water Solubility: Soluble in 0.1M NaOH. Insoluble in water or in methanol.
• λmax: 268nm(MeOH)(lit.)
• Merck: 14,3004
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

Description and Uses

Diazoxide is a nondiuretic derivative of thiazides that dramatically reduces blood pressure by direct relaxation of smooth muscles of the arterioles, possibly as a result of calcium channel activation of smooth musculature in arterioles. It has a weak effect on the venous system and on the heart. In addition to hypotensive action, diazoxide causes a sharp increase in the level of glucose in the blood as a result of the inhibition of insulin release from adrenal glands. Some of the undesirable effects are water and sodium ion retention in the body and increased concentrations of uric acid in the blood. It is used in urgent situations where blood pressure needs to be reduced in severe hypertension. Diazoxide is not used for essential hypertension. A synonym of this drug is hyperstat.

wound healing agent

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P264-P270-P301+P312-P302+P352-P305+P351+P338
• Hazard Codes: Xn
• Risk Statements: 22-36/37/38
• Safety Statements: 22-26-36
• WGK Germany: 3
• RTECS: DK8185000
• HS Code: 2934990002