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A4279920

Diazoxide , ≥98% , 364-98-7

Synonym(s):
7-Chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide

CAS NO.:364-98-7

Empirical Formula: C8H7ClN2O2S

Molecular Weight: 230.67

MDL number: MFCD00078578

EINECS: 206-668-1

Pack Size Price Stock Quantity
250mg RMB87.20 In Stock
1g RMB249.60 In Stock
5g RMB880.00 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: >310°C
Boiling point: 414.8±47.0 °C(Predicted)
Density  1.3767 (rough estimate)
refractive index  1.6300 (estimate)
storage temp.  2-8°C
solubility  0.1 M NaOH: soluble
form  Solid
pka pKa 8.5 (Uncertain)
color  White
Water Solubility  Soluble in 0.1M NaOH. Insoluble in water or in methanol.
λmax 268nm(MeOH)(lit.)
Merck  14,3004
Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

Description and Uses

Diazoxide is a nondiuretic derivative of thiazides that dramatically reduces blood pressure by direct relaxation of smooth muscles of the arterioles, possibly as a result of calcium channel activation of smooth musculature in arterioles. It has a weak effect on the venous system and on the heart. In addition to hypotensive action, diazoxide causes a sharp increase in the level of glucose in the blood as a result of the inhibition of insulin release from adrenal glands. Some of the undesirable effects are water and sodium ion retention in the body and increased concentrations of uric acid in the blood. It is used in urgent situations where blood pressure needs to be reduced in severe hypertension. Diazoxide is not used for essential hypertension. A synonym of this drug is hyperstat.

wound healing agent

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P264-P270-P301+P312-P302+P352-P305+P351+P338
Hazard Codes  Xn
Risk Statements  22-36/37/38
Safety Statements  22-26-36
WGK Germany  3
RTECS  DK8185000
HS Code  2934990002

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